This review offers a comprehensive overview of current knowledge on the characterization of mammalian-derived exosomes, their application as drug delivery systems for neurological disorders, and ongoing clinical trials involving exosome-loaded cargo. Despite their promising attributes, a significant challenge ...
Engineered exosome-based drug delivery system for synergistic cancer therapy via autophagy inhibition and chemotherapy. Credit: Hua X., Liu Y., Liu X. et al Ovarian cancer is one of the most common malignancies in women worldwide. Unlike breast cancer, ovarian cancer lacks early diagnostic marker...
1. Harnessing exosomes as cutting-edge drug delivery systems for revolutionary osteoarthritis therapy.（利用外泌体作为革命性的骨关节炎治疗的尖端药物传递系统。）发布日期: 2023-07-15 作者:Lu Jun , Zhang Yan , Yang Xinquan , Zhao Hongmou 期刊:BIOMEDICINE & PHARMACOTHERAPY 摘要：外泌体是一种重要的...
The effectiveness of exosome-based therapies is limited by factors such as angiogenesis, fibrotic signaling, hypoxia in the TME, which can hinder drug delivery and intra-tumor infiltration whilst increasing tumor resistance to drugs [202]. Therefore, methods of exerting effective therapeutic efficiency ...
exosome, nanoparticles, drug delivery systems, imaging probes, therapeuticsExosomes, a subgroup of extracellular vesicles (EVs), have been recognized as ... X Luan,K Sansanaphongpricha,I Myers,... - 《Acta Pharmacologica Sinica》 被引量: 49发表: 2017年 RNAi delivery by exosome-mimetic nanovesic...
[7]. The mechanism and progression of bladder cancer still remain vague. What’s more, a noninvasive and accurate diagnosis or prognosis biomarker and engineered exosomes for drug delivery of bladder cancer is urgently needed. As we outlined above, exosomes and their contents are deeply involved ...
Disease Treatment Through ExosomeTargeted Drug Delivery System 外泌体由于小尺寸,来源于生物体,可以任意穿过生物膜甚至是BBB,且没有免疫原性,具有靶向目标组织位点。利用受体调节的内吞作用与靶向组织交流。但天然外泌体具有弱靶向能力,易被体内清除,因此需要通过修饰成工程化外泌体。
BOC Sciences' Exosome DNA/RNA Delivery Service BOC Sciences offers state-of-the-art exosome drug delivery services to meet the diverse needs of our clients in nucleic acid (eg. siRNA) delivery. Our expert team specializes in the isolation, characterization, and engineering of exosomes for targeted...
1. Harnessing exosomes as cutting-edge drug delivery systems for revolutionary osteoarthritis therapy. (利用外泌体作为革命性的骨关节炎治疗的尖端药物传递系统。) 发布日期 : 2023-07-15 作者:Lu Jun , Zhang Yan , Yang Xinquan , Zhao Hongmou ...
27,28,29,30 Pharmacologically, the proliferation and osteogenesis could be rescued by targeted drug delivery to BMSCs.31,32 Therefore, targeting BMSCs is a feasible strategy to correct its commitment and promote osteoblastogenesis in IBDs.33 Exosomes, as natural extracellular vesicles with ideal ...