外泌体对免疫应答的调节也可能涉及免疫调节分子的呈递,如PD-L1(程序性细胞死亡配体1)和FasL(Fas细胞表面死亡受体配体)。黑色素瘤来源的外泌体上的PD-L1在体内抑制CD8 + T细胞抗肿瘤功能,癌细胞来源的外泌体以PD-L1依赖的方式阻断树突状细胞成熟和迁移。此外,癌细胞来源的PD-L1 + 外泌体促进荷瘤小鼠引流淋巴结...
Mesenchymal stem cells (MSCs) show high expression of PD-L1. Exosomes can transmit signals between tumor cells and stromal cells; however, the effect of tumor-derived exosomes on stromal cell signaling pathways is unclear. The expression of PD-L1 in bone marrow mesenchymal stem cells (BMMSCs) ...
目的 研究肾细胞癌源性exosomes诱导人外周血单核细胞分化为髓源性抑制细胞及该细胞PD-L1分子表达情况的效应.方法 超滤和蔗糖重水密度梯度离心相结合的方法分离纯化肾细胞癌源性exosomes.Ficoll密度梯度离心法分离外周血单个核细胞,贴壁法获取外周血单核 细胞.倒置显微镜观察获得的单核细胞形态.流式细胞仪检测单核细胞比...
programmed cell death ligand 1 (PD-L1) can bind to programmed cell death protein 1 (PD-1) on CD8 + T cells, inhibiting T-cell activity, facilitating immune escape, and promoting tumor immune tolerance [27]. Exosomes derived from tumor cells contain various microRNAs, long noncoding RNAs...
PD-L1Tumors escape immune attack by upregulating the surface expression of PD-L1, which interacts with PD-1 on T cells to activate immune inhibitory signaling. Anti-PD-1 treatments can effectively block this inhibitory signaling and activate antitumor immune responses. However, anti-PD-1 treatment...
Plasma exosomal PD-L1 expression showed high correlation with PD-L1 expression of tumor tissues. Exosomal PD-L1 expression could represent PD-L1 expression of tumor tissues and might be a potential predictive marker for anti-PD-1/PD-L1 therapy. Legal entity responsible for the study Jifeng Feng...
Exosomal PD-L1 induces osteogenic differentiation and promotes fracture healing by acting as an immunosuppressant. Bioact Mater. 2021;3(13):300–11. Google Scholar Hade MD, Suire CN, Suo Z. Mesenchymal stem cell-derived exosomes: applications in regenerative medicine. Cells. 2021;10(8):1959....
In cancer, Chen and colleagues discovered that exosomal PD-L1 secreted by metastatic lesions enhances tumor immunosuppression and is associated with poor clinical response. Lastly, Fan et al recently showed that cancer cells can use an alternative exosomal development pathway to create pro-tumorigenic ...
checkpoint inhibitors. Using mouse models, Wang et al. showed that elimination of cancer-derived exosomes using GW4869, along with ferroptosis inducer, significantly inhibited exosomal PD-L1-mediated immunosuppression, restored anti-tumor immune response, and reduced metastasis [153]. Other compounds of...
此外，外泌体可能通过免疫调节分子的呈递，如PD-L1和FasL，影响免疫反应。在癌症先天性免疫反应中，外泌体也起到重要作用，可能限制补体介导的裂解，降低对癌细胞的细胞毒性，或通过MHC-Ⅱ、CD86、LFA-1和ICAM-1的表达，诱导B细胞和T细胞的增殖。在神经退行性疾病中，外泌体的生物发生和神经元细胞中...