In addition to increasing the expression of programmed death-ligand 1 (PD-L1), tumor cells can also secrete exosomal PD-L1 to suppress T cell activity. Emerging evidence has revealed that exosomal PD-L1 resists immune checkpoint blockade, and may contribute to resistance to therapy. In this sce...
Here, we describe an alternative mechanism of PD-L1 activity involving its secretion in tumor-derived exosomes. Removal of exosomal PD-L1 inhibits tumor growth, even in models resistant to anti-PD-L1 antibodies. Exosomal PD-L1 from the tumor suppresses T cell activation in the draining lymph ...
T cell suppression in hepatocellular carcinoma by promoting exosomal PD-L1 transport into tumor-associated macrophagesThe immunosuppressive microenvironment plays an important role in tumor progression and immunotherapy responses. Golgi membrane protein 1 (GOLM1) is correlated to hepatocellular carcinoma (HCC)...
Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury Cell Death Differ., 27 (1) (2020), pp. 210-226 Google Scholar [40] W. Li, H. Zhang, X. Niu, X. Wang, Y. Wang, Z. He, H. Yao Effects and mechanisms of cavidine protecting mice...
[106]. Poggio et al. have depicted exosomes from various cancers, including CRC, carry PD-L1 on their surface. PD-L1 can systematically bind to its receptor PD-1 on T cells in the regional lymph nodes, resulting in the inhibition of T cells. Interestingly, removal of exosomal PD-L1 ...
in this cancer type (34). Other studies have confirmed exosomal PD-L1 in melanoma, prostate cancer, breast cancer, glioblastoma, head and neck cancer, lung cancer, and other tumors (35,36). However, the success of immunotherapy depends on the expression profile of these different ICPs. ...
Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. Nat Cell Biol. 2018;20:597–609. Article CAS PubMed PubMed Central Google Scholar Sanmamed MF, Rodriguez I, Schalper KA, Onate C, Azpilikueta A, Rodriguez-Ruiz ...
Dying tumor cell-derived exosomal miR-194-5p potentiates survival and repopulation of tumor repopulating cells upon radiotherapy in pancreatic cancer. Mol. Cancer 2020, 19, 68. [CrossRef] [PubMed] 63. Kosela-Paterczyk, H.; Paziewska, A.; Kulecka, M.; Balabas, A.; Kluska, A.; ...