growth Mohammad Reza Nikmaneshi1,2, Bahar Firoozabadi2*, Aliasghar Mozafari2 & Lance L. Munn1* The search for efficient chemotherapy drugs and other anti-cancer treatments would benefit from a deeper understanding of the tumor microenvironment (TME) and its role in tumor ...
improve how the body responds to insulin. Because SHP2 is also implicated in cancer, inhibitors have already been developed and could be tested for treatment of metabolic diseases. These results illuminate the fundamentals of a key metabolic pathway, and may help in treatment of type 2 diabetes....
T cells with a chimeric antigen receptor (CAR) specific for HERV-K (HML-2) Env protein (K-CAR) can greatly decrease the proliferation of breast cancer cells and cytotoxicity [108]. In xenograft experiments, K-CAR significantly inhibited tumor growth and metastasis to other organs. Anti-HERV-...
About half of all cancer patients show a syndrome of cachexia, characterized by anorexia and loss of adipose tissue and skeletal muscle mass. Cachexia can have a profound impact on quality of life, symptom burden, and a patient’s sense of dignity. It is a very serious complication, as weig...
Inflammation, Infection, Cancer and All That…The Role of Paraoxonases Chapter 1Introduction The paraoxonases PON1, PON2, and PON3 are members of esterase family enzymes and are highly conserved within and between species (figure1) (Teiberet al.2018). Phylogenetic analysis has revealed that PON...
In our continuing examination of the role of exposomes in autoimmune disease, we use this review to focus on pathogens. Infections are major contributors to the pathophysiology of autoimmune diseases through various mechanisms, foremost being molecular m