Papillary carcinoma is an uncommon type of breast cancer. Additionally, patients with huge breast papillary carcinoma are extremely rare in clinical practice. To improve therapeutic effect on such patients, it is urgent to explore biologically and clinic
Despite continuous advances in the knowledge of breast cancer pathophysiology, this type of neoplasia remains a leading cause of cancer-related death in women worldwide. Carcinogenesis takes a progressive course from somatic mutations, alteration of the DNA repair mechanisms, inhibition of growth suppress...
Thus, the tumor matrix modulates each of the classically defined hallmarks of cancer promoting the growth, survival and invasion of the cancer. Moreover, various ECM-derived components modulate the immune response affecting T cells, tumor-associated macrophages (TAM), dendritic cells and cancer-...
The combination of spontaneous and induced models holds potential for finding the answer to breast cancer etiology, and providing novel strategies to screen, prevent and treat this disease in a more effective way. In general, mammary glands in women are more complex than in female dogs and ...
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Metabolic reprogramming is being recognized as a fundamental hallmark of cancer, and efforts to identify drugs that can target cancer metabolism are underway. In this study, we used human breast cancer (BC) cell lines and established their invading phenotype (INV) collected from transwell inserts to...
Seroma formation after breast cancer surgery: Incidence and predicting factors The pathophysiology of seroma formation has yet to be determined. Therefore, the present study was undertaken to calculate the incidence of postoperative s... PA Woodworth,MF Mcboyle,SD Helmer,... - 《American Surgeon》...
Progestins have arisen as important players in breast cancer etiology. Compelling experimental and clinical evidence points to a critical role for progesterone and the nuclear progesterone receptor (PR) in controlling mammary gland tumorigenesis [1–8]. However, the molecular mechanisms through which pro...
Towards an integrated model for breast cancer etiology: the crucial role of the number of mammary tissue-specific stem cells. Breast Cancer Res. 2005;7(1):13–7. Article PubMed Google Scholar Hens JR, Wysolmerski JJ. Key stages of mammary gland development: molecular mechanisms involved in...
Trichopoulos D, Lagiou P, Adami HO (2005) Towards an integrated model for breast cancer etiology: the crucial role of the number of mammary tissue-specific stem cells. Breast Cancer Res. 7(1):13–7 PubMedGoogle Scholar Hens JR, Wysolmerski JJ (2005) Key stages of mammary gland developm...