The presence of laminin in the extracellular matrix promotes cell attachment and viability, facilitating the self-organization of primary breast cancer cells into tumoroids [22]. Additionally, breast cancer stem cells produce a laminin matrix that promotes self-renewal and tumor initiation by engaging ...
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited targeted therapies and high rates of recurrence. We previously showed that Efp promotes TNBC cell proliferation by regulating cell cycle-related gene expression. Recent studies showed that ZCCHC3 interacts with Efp...
growth Mohammad Reza Nikmaneshi1,2, Bahar Firoozabadi2*, Aliasghar Mozafari2 & Lance L. Munn1* The search for efficient chemotherapy drugs and other anti-cancer treatments would benefit from a deeper understanding of the tumor microenvironment (TME) and its role in tumor ...
It is generally accepted that tumor blood flow, microcirculation, oxygen and nutrient supply, tissue pH distribution, lactate levels, and the bioenergetic status— factors that are usually closely linked and that define the so-called pathophysiological..
or be inherited. Breast cancer in men is much less common than benign gynaecomastia, and the two conditions can usually be distinguished by a careful physical examination. Estrogens are known to stimulate the growth of breast tissue, whereas androgens inhibit it; most cases of gynaecomastia resu...
Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells. FEBS Lett. 2005;579:6343–9. CAS PubMed Google Scholar Maccarrone M, De Chiara V, Gasperi V, Viscomi MT, Rossi S, Oddi S, et al...
family history of breast cancer Increased age Early menarche, nulliparity, late menopause, late parity (high estrogen) ionizing radiation BRCA1 and BRCA2 tumor suppressor genes involved in DNA damage response mutation result in hereditary breast cancer, ovarian cancer ...
What is a malignant tumor? What is squamous cell cancer? What is a melanoma tumor? What is the pathogenesis of breast cancer? What is differentiated thyroid cancer? What is a melanoma lesion? What is carcinoma cancer of the thyroid? What is pancreatic cancer? What is intestinal cancer? What...
Lower levels of estrogen cause loss of bone density, breast atrophy, and mood swings in women. These side effects are the reason hormone therapy is only approved for up to 6 months in duration [74]. However, for patients which do not express the desire to conceive, hormonal therapy is a...
MR imaging of tumor-associated macrophages. Onco Targets Ther. 2012;1(4):507–9. https://doi.org/10.4161/onci.19456. Article Google Scholar Danese S. Immune and nonimmune components orchestrate the pathogenesis of inflammatory bowel disease. Am J Physiol Liver Physiol. 2011;300(5):G716–...