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Evaluation of factors related to late recurrence--later than 10 years after the initial treatment--in primary breast cancer. Treatment decisions for breast cancer are commonly based on the information derived from the immunohistochemistry (IHC) of biological markers. The common ... R Nishimura,T ...
Molecular Pathology of Breast Cancer 来自 学术范 喜欢 0 阅读量: 8 作者: KH Allison 摘要: Pathologists are now more than ever "diagnostic oncologists" and serve a critical role as clinical consultants on the biology of disease. In the last decade and a half, molecular information has ...
A small proportion of breast-cancer cases, in particular cancers diagnosed in young patients are attributable to a hereditary predisposition to the disease, which is transmitted as a highly penetrant autosomal dominant trait. There has been considerable progress in the identification of the genes respon...
The pathology of early-age onset breast cancer is considered here from three perspectives: 1) benign proliferative disease, 2) the cancers themselves, and 3) familial and hereditary breast cancer. Hereditary breast cancer, a subset of familial breast cancer featuring a strong autosomal dominant pedig...
Hereditary breast and ovarian cancer (HBOC) syndrome is most commonly characterized by deleterious germline mutations inBRCA1andBRCA2. HBOC patients are prone to the development of malignant neoplasms in multiple organs including the breast, ovary, and fallopian tube. From a pathological perspectiv...
The pathology of early-age onset breast cancer is considered here from three perspectives: 1) benign proliferative disease, 2) the cancers themselves, and 3) familial and hereditary breast cancer. Hereditary breast cancer, a subset of familial breast cancer featuring a strong autosomal dominant pedig...
The Pathology of Familial Breast Cancer: Predictive Value of Immunohistochemical Markers Estrogen Receptor, Progesterone Receptor, HER-2, and p53 in Patien... PURPOSE: The morphologic and molecular phenotype of breast cancers may help identify patients who are likely to carry germline mutations in ...
Scientists have discovered a previously unknown mechanism by which estrogen prepares cells to divide, grow and, in the case of estrogen-positive breast cancers, resist cancer drugs. The researchers say the work reveals new targets for breast cancer thera