Triple negative breast cancer (TNBC) is a subtype of breast tumor lacking hormone receptors expression and HER2 gene amplification and represents 24% of newly diagnosed breast neoplasms. In this review, pathological aspects of triple-negative breast cancer are illustrated, with particular attention to ...
Triple-negative breast cancer (TNBC) is defined by the absence of estrogen/progesterone receptor and HER2 expression. Basal-like breast cancer is based upon molecular classification of breast cancer (geneexpression studies) and should be contrasted to TNBC. In one study approximately 77% of basal-...
Objective: To explore the expression of CXCL13 in triple-negative breast cancer( TNBC),and its correlation with clinical pathology and prognosis. Methods: The expression levels of CXCL13 in 73 TNBC tissue samples and 24 paracancerous normal breast tissue samples were detected using immunohistochemical...
The absence of a robust risk stratification tool for triple negative breast cancer (TNBC) underlies imprecise and nonselective treatment of these patients with cytotoxic chemotherapy. This study aimed to interrogate transcriptomes of TNBC resected samples using next generation sequencing to identify novel ...
Social determinants of health inequalities. Lancet 365, 1099–1104 (2005). Article PubMed Google Scholar Dietze, E. C., Sistrunk, C., Miranda-Carboni, G., O’Reagan, R. & Seewaldt, V. L. Triple-negative breast cancer in African-American women: disparities versus biology. Nat. Rev....
et al. histoCAT: analysis of cell phenotypes and interactions in multiplex image cytometry data. Nat. Methods 14, 873–876 (2017). Article CAS PubMed PubMed Central Google Scholar Keren, L. et al. A structured tumor-immune microenvironment in triple negative breast cancer revealed by ...
a number of morphological features have been described inBRCA-associated breast and tubo-ovarian cancers. For example, breast cancers diagnosed inBRCA1-mutation carriers are frequently of a high Nottingham grade and display medullary morphology and a triple-negative and/or a basal-like immunophen...
Generally, breast cancer in native African women is characterized by young age at onset, occurrence in multiparous premenopausal patients, advanced stage at diagnosis, large tumor size, high‐grade and triple‐negative phenotype, with cor‐ respondingly poor prognosis. In Sudan, it was reported that...
Left lobe of liver, core biopsy: Poorly differentiated carcinoma, consistent with breast primary (see comment) Comment: The patient's past history of triple negative breast cancer is noted. Immunostains performed on the biopsy block show that the tumor cells are positive for pancytokeratin, TRPS1...
A conversation with David Rimm, the author of a recent study on Triple negative breast cancer, on using a novel statistical algorithm (ONEST) to improve reproducibility of PD-L1 assessment by pathologists. Listen in via Acast | Spotify | or Download Associated article: Prospective multi-instituti...