Disclosed is the use of partial inhibitors of fatty acid oxidation for the manufacture of a medicament for treating congestive heart failure. The compounds increase cardiac performance without affecting heart rate, blood pressure, or oxygen consumption.Wolff, Andrew A....
Sabbah HN,Chandler MP,Mishima T,et al.Ranolazine,a partial fatty acid oxidation (pFOX) inhibitor,improves left ventricular function in dogs with chronic heart failure[J].J Card Fail,2002,8:416-422.SABBAH HN, CHANDLER MP, MISHIMA T, et al. Ranolazine, a partial fatty acid oxidation (pFOX...
During myocardial ischemia, fatty acids are the principal source of energy, increasing myocardial oxygen consumption and making a decrease in coronary blood flow less well tolerated. Increasing glucose oxidation during myocardial ischemia may improve cardiac efficiency. The pFOX inhibitors have the potentia...
1b). Consistent with previous observations, CP2 robustly activated AMPK after 24 h, when increased phosphorylation of acetyl-CoA carboxylase 1 (ACC1), a biomarker of AMPK target engagement associated with increased fatty acid oxidation15, was evident 4 h after CP2 administration (Fig. 1f,...
Insulin’s effect on substrate oxidation was significantly impaired for both the decrease in fatty acid oxidation and the increase in glucose oxidation. However, insulin-stimulated glucose uptake was normal in the infarcted hearts, consistent with normal insulin-induced phosphorylation of Akt and ...
fatty acid methyl estersoxidation stabilitypartial hydrogenationplasmaOxidation stability is an important biodiesel property. One of the methods to improve oxidation stability is partially hydrogenated fatty acid methyl esters (H〧AME). The present research studied the novel production technique of H〧AME ...
Cloning, Expression, and Characterization of Three New Mouse Cytochrome P450 Enzymes and Partial Characterization of Their Fatty Acid Oxidation Activities 来自 国家科技图书文献中心 喜欢 0 阅读量: 48 作者: Wang,H. 摘要: The mammalian CYP2C subfamily is one of the largest and most complicated in...
Any enzyme present in an inventive composition may be protected, particularly during storage, from damage, for example, inactivation, denaturation or decay, for instance by physical influences, oxidation or proteolytic cleavage. For this purpose, inventive compositions may comprise stabilizers. One group...
The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure. Herz. 2002;27(7):621-36.Rupp H, Zarain-Herzberg A, Maisch B. The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure. Herz 27...
PARTIAL FATTY ACID OXIDATION INHIBITORS IN THE TREATMENT OF CONGESTIVE HEART FAILUREDisclosed method treats the inhibitor of congested haert failure and local fat acid oxidase. The compoundincrease cardiac function is without influencing heart rate, blood pressure or oxygen consumption.WOLFF Andrew A....