Nature | 重要突破!袁学军等团队合作首次证实,改变心肌细胞能量代谢,可实现心脏再生 心肌细胞出生后成熟的特征是从糖酵解到脂肪酸氧化、染色质重构和退出细胞周期的代谢转变,这为成人心脏再生建立了屏障。 2023年10月27日,德国马克 - 金娃学术于20231030发布在抖音,
Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle, instating a barrier for adult heart regeneration1,2. Here, to explore whether metabolic reprogramming can overcome this barrier an...
Inhibition of fatty acid oxidation by 2-bromooctanoate - Raaka, Lowenstein - 1979 () Citation Context ... that the enzymes in the fatty acid de novo synthesis pathway are not target enzymes. 2-Bromooctanoic acid is converted to 2-bromooctanoyl-CoA and 2-bromo-3-ketooctanoyl-CoA in rat ...
InhibitionoffattyacidoxidationbyetomoxirimpairsNADPHproductionand increasesreactiveoxygenspeciesresultinginATPdepletionandcelldeath inhumanglioblastomacells ☆ LisaS.Pike a ,AmyL.Smift a ,NicoleJ.Croteau b ,DavidA.Ferrick a ,MinWu a, ⁎ a SeahorseBioscience,NorthBillerica,MA01862,USA b DepartmentofMedica...
Pediatric Research publishes original papers, invited reviews, and commentaries on the etiologies of diseases of children and disorders of development, extending from molecular biology to epidemiology. Use of model organisms and in vitro techniques relevant to developmental biology and medicine are ...
Inhibition of fatty-acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans... R Camarda,AY Zhou,RA Kohnz,... - 《Cancer Research...
In contrast, 4-pentenoic acid, an established inhibitor of long-chain fatty acid β-oxidation, had little effect on the metabolism of decanoate. It is concluded that the title compounds are potent, broad-spectrum inhibitors of fatty acid β-oxidation, a property which may be of key ...
Intravenous administration of high doses of tetracycline may produce severe microvesicular steatosis of the liver in man. A similar disease is observed after ingestion of drugs which inhibit hepatic mitochondrial fatty acid β-oxidation and in subjects with various inborn defects in this metabolic pathw...
摘要: Studies the physiological effects of hyperglycemia on the secretion rates of splanchnic fatty acid oxidation and triacylglycerol (TG) in healthy men. Physiological effects of hypertriglyceridemia; Methodology; Results and discussion.被引量: 168 ...
We report here that this increase in apoptosis (assessed morphologically by TdT-mediated dUTP nick- end labeling staining) is preceded (24 h of incubation) by inhibition of fatty acid oxidation, by increases in diacylglycerol synthesis, the concentration of malonyl CoA, and caspase-3 activity, ...