de Almodovar and F. J. Oliver (2009) PARP-1 is involved in autophagy induced by DNA damage. Autophagy 5, 61-74.Munoz-Gamez JAR-VJ, Quiles-Perez R, Aguilar-Quesada R, Martin-Oliva D, de Murcia G, Menissier de Murcia J, Almendros A, Ruiz de Almodovar M et al (2009) PARP-1 is...
PARP-1 has been implicated in different pathways leading to cell death and its inhibition potentiates chemotherapy-induced cell death. Whether PARP-1 participates in the cells decision to commit to autophagy following DNA damage is still not known. To address this issue PARP-1 wild type and ...
PARP1 is an important, positive regulator of autophagy induced by DNA damage, ROS, and starvation22,23. PARP1 activation and ATP depletion mediate cell death and autophagy via AMPK activation and mTOR suppression24. Furthermore, PARP1 inhibitors have antitumor activity in some types of cancer25....
( ADP~ribose) polymeraseꎬ PARPs] 在肝内细胞 DNA 损伤与修复中具有重要意义( 尤其是 PARP~1) ꎮ 于此ꎬ该文通过对 PARP~1 基因的结构与功能 分析ꎬ发现其在肝内细胞 DNA 损伤与修复中ꎬ可通过 NAD+ 及能量代谢调节线粒体稳态,调控炎症信号通路 NF~κB,激活 转录激活蛋白 1( AP~1) 和抑制 ...
141 Finally, treatment of cells with the G4 ligand 20A led to the upregulation of genes associated with apoptosis and autophagy, which emphasizes the anti-tumorigenic effect of this ligand. Importantly, additional studies have recently begun to link PARP1 and DNA G4 stabilization by ligands, ...
Even though EGFR transactivation can be induced by UV irradiation in keratinocytes [35], it remains unknown of the effect of UV radiation on autophagy in retinal cells, not to mention its pro-survival or pro-death role, the underlying signaling cascade and interplay with DNA damage repair. ...
B. Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol 16, 663–669 (2004). Article CAS PubMed Google Scholar Chan, F. K. et al. A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. J Biol Chem...
In addition, NAT10 participates in multiple cellular processes through its lysine acetyltransferase activity toward non-ribosomal targets, such as histones [11], α-tubulin [12], centrosome protein CCDC84 [13], tumor suppressor p53 [14], and autophagy regulator Che-1 [15]. Recently, we ...
PARP-1: friend or foe of DNA damage and repair in tumorigenesis? Cancers 2013; 5: 943–958. 11. Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P. Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol 2014; 15...
Stavudine (BMY-27857) 是一种口服活性核苷逆转录酶抑制剂,还抑制线粒体 DNA 的复制,具有抗HIV-1和HIV-2的活性。它降低 NLRP3 炎症小体激活,调节淀粉样 β 自噬,诱导细胞凋亡。 ApoptosisAutophagyHIV ProteaseNOD-like Receptor (NLR)Nucleoside Antimetabolite/AnalogReverse Transcriptase ...