[3] R.X. Huang, P.K. Zhou, DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer,Signal Transduct Target Ther, 5 (2020) 60. [4] J. Murai, Y. Pommier, BRCAness, Homologous Recombinat...
PARP-1 is widely recognized as a first-line responder molecule in DNA damage response (DDR). Here, we review the full cycle of detecting DNA damage by PARP-1, PARP-1 activation upon DNA binding, and PARP-1 release from a DNA break. We also discuss the allosteric consequence upon binding...
Similarly, ATM is involved in controlling cell proliferation as well as managing DNA damage response signaling [181]. This means that while mutations in these genes may lead to unregulated tumor growth, it also makes them particularly reliant on alternative pathways for managing DNA damage. PARP-...
signaling pathwayꎬactivate transcriptional activator protein 1( AP~1) ꎬand inhibit AMPK~mTOR pathway through NAD+ and energy metabolism in cellular DNA injury and repair in hepatic cellsꎬthereby promo~ ting HF.This suggests that PARP inhibition ( PAPRI) is a promising therapeutic strategy ...
DNA damage signaling BiNGO analysis revealed similar significance for the "DNA repair" branches of PARP-1 and PARP-2 (Figure 3 and 4). Both PARP-1 and PARP-2 immunoprecipitates contained KU70 and KU80, two proteins involved in DNA double-strand break repair by NHEJ, thus confirming the re...
6. Zhou, Y., et al., The kinase CK1varepsilon controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3.Nat Immunol, 2016. 17(4): p. 397-405. 7. Weitzman, M.D. and A. Fradet-Tur...
However, while PARP1 does localize to DNA strand breaks, it is also not known whether there is any further global redistribution PARP1 or a relationship to the redistribution of SIRT1. DNA damage signaling pathway Both SIRT1 and PARP1 are DNA damage responders and the absence of either of ...
We also report several lines of evidence suggesting that intramitochondrial PARP-1 plays a role in mitochondrial DNA (mtDNA) damage signaling and/or repair. First, we show that PARP-1 binds to different regions throughout the mtDNA. Moreover, we demonstrated that the depletion of either PARP-...
DNA Damage Response (DDR) and DNA repair pathways are emerging as potent, ubiquitous suppressors of innate immune signaling in human cells. Here, we show that human cells surviving depletion of the Single Strand Break (SSB) repair protein PARP1 undergo p21-dependent senescence or cell cycle check...
Oxidative DNA damage and augmentation of poly(ADP-ribose) polymerase/nuclear factor-kappa B signaling in patients with type 2 diabetes and microangiopathy Int J Biochem Cell Biol, 39 (2007), pp. 1673-1684 View PDFView articleView in ScopusGoogle Scholar 83 W.J. Chang, R. Alvarez-Gonzalez ...