[3] R.X. Huang, P.K. Zhou, DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer,Signal Transduct Target Ther, 5 (2020) 60. [4] J. Murai, Y. Pommier, BRCAness, Homologous Recombinat...
PARP-1 is widely recognized as a first-line responder molecule in DNA damage response (DDR). Here, we review the full cycle of detecting DNA damage by PARP-1, PARP-1 activation upon DNA binding, and PARP-1 release from a DNA break. We also discuss the allosteric consequence upon binding...
4C). DNA damage response is a dynamic process; the initial stage involves the activation of the DNA damage cascade, followed by the participation of intermediate factors involved in the physical repair of damaged DNA, and ends with the late factors which stop the signaling cascade returning the ...
6. Zhou, Y., et al., The kinase CK1varepsilon controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3.Nat Immunol, 2016. 17(4): p. 397-405. 7. Weitzman, M.D. and A. Fradet-Tur...
DNA incision, 3'-to lesion nucleotide-excision repair, DNA incision, 5'-to lesion double-strand break repair transcription from RNA polymerase II promoter protein ADP-ribosylation cellular response to DNA damage stimulus mitochondrion organization transforming growth factor beta receptor signaling pathway ...
DNA damage shuts down genome-wide transcription to prevent transcriptional mutagenesis and to initiate repair signalling, but the mechanism to stall elongating RNA polymerase II (Pol II) is not fully understood. Central to the DNA damage response,
(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ...
Many additional functions of PARP-1 have now been demonstrated in biochemical and molecular signaling [8]. Apart from its role in repairing DNA damage, PARP-1 also plays important roles in transcription, cardiac remodeling, vasoconstriction, regulation of astrocyte and microglial function, long term ...
DNA incision, 3'-to lesion nucleotide-excision repair, DNA incision, 5'-to lesion double-strand break repair transcription from RNA polymerase II promoter protein ADP-ribosylation cellular response to DNA damage stimulus mitochondrion organization transforming growth factor beta receptor signaling pathway ...
Cellular LocalizationNucleus. Nucleus, nucleolus. Localizes at sites of DNA damage. Concentration0.2 mg/mL BufferPhosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. Purification MethodAffinity purification Research AreasCancer, Cell Biology, Epigenetics and Nuclear Signaling,...