Wang Z, Wang F, Tang T, Guo C (2012) The role of PARP1 in the DNA damage response and its application in tumor therapy. Front Med China 6:156-164. doi:10.1007/s11684-012-0197-3Wang Z, Wang F, Tang T, Guo C. The role of PARP1 in the DNA damage response and its application...
Peng, B., R. Shi, J.Bian, Y. Li, P. Wang, H. Wang, et al., PARP1 and CHK1 coordinate PLK1 enzymaticactivity during the DNA damage response to promote homologousrecombination-mediated repair.Nucleic Acids Res(2021) 49...
Interestingly, the data obtained through this study revealed that PARP1 was co-immunoprecipitated with checkpoint kinase 2 (CHK2), and the interaction was increased after oxidative DNA damage. Moreover, CHK2 depletion resulted in a reduction in overall PARylation. To further explore the functional ...
近日,来自军事医学研究院辐射医学研究所周平坤研究员带领团队在Molecular Therapy发表了他们最新的研究成果,题目是Targeting PARP1 modulates METTL3 promoter chromatin accessibility and associated LPAR5 RNA m6A methylation to enhance cancer cell ...
The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this ...
Plummer ER. etc.Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1. Clin Cancer Res. 2005 May 1;11(9):3402-9. doi: 10.1158/1078-0432. ...
Whether PARP-1 participates in the cells decision to commit to autophagy following DNA damage is still not known. To address this issue PARP-1 wild type and deficient cells have been treated with a dose of doxorubicin that induces autophagy. Electron microscopy examination and GFP-LC3 transfection...
The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this ...
DNA and connective tissue hyperplasia can induce cirrhosisꎬeventually leading to organ failureꎬcancer proliferation or even death.Poly( ADP~ribose) polymerase ( PARPs) are key enzymes implicated in hepatocyte DNA repair processes ( especially PARP~1) .In this paperꎬthrough the structural and ...
Mukherjee RM, Shravanti GV, Jakkampudi A, et al. Reduced Expression of DNA Damage Repair Genes High Mobility Group Box1 and Poly(ADP-ribose) Polymerase1 in Inactive Carriers of Hepatitis B Virus Infection-A Possible Stag...