Most importantly, anti-MALAT1 therapy induced DNA damage and cell apoptosis in vivo, indicating that MALAT1 could serve as a potential novel therapeutic target for MM treatment.doi:10.1038/s41375-018-0104-2Yi HuJianhong LinHua FangJing Fang...
Role of the PARP1/NF-魏B Pathway in DNA Damage and Apoptosis of TK6 Cells Induced by HydroquinoneHydroquinone(HQ) is a widely used industrial raw ... Haipeng Wu,Huan Tang,Xiangli Zou,... 被引量: 0发表: 0年 WRN, the protein deficient in Werner syndrome, plays a critical structural rol...
( ADP~ribose) polymeraseꎬ PARPs] 在肝内细胞 DNA 损伤与修复中具有重要意义( 尤其是 PARP~1) ꎮ 于此ꎬ该文通过对 PARP~1 基因的结构与功能 分析ꎬ发现其在肝内细胞 DNA 损伤与修复中ꎬ可通过 NAD+ 及能量代谢调节线粒体稳态,调控炎症信号通路 NF~κB,激活 转录激活蛋白 1( AP~1) 和抑制 ...
该细胞死亡途径有4个关键步骤,PARP-1的过度激活导致PAR的积累;过量的PAR诱导凋亡诱导因子(apoptosis inducing factor,AIF)从线粒体释放;后者结合巨噬细胞迁移诱导因子(macrophage migration inhibitory factor,MIF),携带MIF进入细胞核;在细胞核中将基因组D...
is a nuclear protein involved in the regulation of various biological processes including apoptosis, DNA repair for the maintenance of genome integrity, epigenetic marking of chromatin, assembly of higher-order chromatin structures, transcriptional activation, differentiation, proliferation, and cell cycle. ...
PARP is a family of 17 intracellular enzymes associated with the cellular stress response, chromatin remodeling, DNA repair, and apoptosis [165]. In general, PARPs mediate reversible posttranslational modification via synthesis of nucleic acid mimic molecules known as poly-ADP-ribose (PAR) from nicot...
PARP-1 expression and activity in primary human lung cells Activation of poly(ADP-ribose) polymerase-1 (PARP-1) in response to DNA damage is an important mechanism to keep homeostasis or to trigger apoptosis. The e... M Ahmad,A Torky,F Glahn,... - 《Archives of Toxicology》 被引量: ...
Through this article we have tried to develop a brief and simplified picture of the principal physiological and pathophysiological roles governed by PARP-1 and its therapeutic implications. 展开 关键词: PARP-1 Apoptosis Necrosis DNA repair PARP inhibitors DOI: 10.1016/j.vph.2010.06.003 被引量...
and a 24-kDa NH2-terminal peptide by caspases during the apoptotic process. The appearance of PARP fragments is commonly considered as an important biomarker of apoptosis. In addition to caspases, other proteases like calpains, cathepsins, granzymes and matrix metalloproteinases (MMPs) have also ...
Description: This HLNC4 monoclonal antibody reacts with human poly (ADP-ribose) polymerase (PARP1). This ubiquitous 116 kDa nuclear enzyme is involved in DNA repair. During apoptosis, active caspases -3, -6 and -7 cleave PARP1 after Asp214, thereby inactivating PARP1 and generating...