该细胞死亡途径有4个关键步骤,PARP-1的过度激活导致PAR的积累;过量的PAR诱导凋亡诱导因子(apoptosis inducing factor,AIF)从线粒体释放;后者结合巨噬细胞迁移诱导因子(macrophage migration inhibitory factor,MIF),携带MIF进入细胞核;在细胞核中将基因组DN...
Poly(ADP-ribose) polymerase-1 (PARP-1), also designated PARP, is a nuclear DNA-binding zinc finger protein that influences DNA repair, DNA replication, modulation of chromatin structure and apoptosis. In response to genotoxic stress, PARP-1 catalyzes the transfer of ADP-ribose units from NAD+...
PARP1 (poly(ADP-ribose) polymerase 1) is a nuclear protein involved in the regulation of various biological processes including apoptosis, DNA repair for the maintenance of genome integrity, epigenetic marking of chromatin, assembly of higher-order chromatin structures, transcriptional activation, differe...
PARP is important for genomic stability but dispensable in apoptosis. Genes Dev. 1997;11:2347-2358. [PubMed] [DOI] 25. Nozaki T, Fujihara H, Watanabe M, Tsutsumi M, Nakamoto K, Kusuoka O, Kamada N, Suzuki H, Nakagama H, Sugimura T. Parp-1 deficiency implicated in colon and ...
检测正常乳腺组织、乳腺良性病变和乳腺癌中PARP-1和caspase-3的表达情况，研究它们与乳腺癌临床病理特征的关系，分析两者在正常乳腺组织、乳腺良性病变和乳腺癌组织之间表达的相关性。为寻找乳腺癌诊断标志物和判断乳腺癌预后的指标提供依据。方法：1收集资料完整的乳腺档案石蜡标本共282例，其中浸润性乳腺癌267例，乳腺...
14 dtime points.HE was used to observe the morphological change of spinal cord tissue.The expression of PARP-1and AIF was detected by immunohistochemistry.The level of cell apoptosis was detected by the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling(TUNEL).Results HE staining ...
PARP 是一种存在于除酵母外所有真核细胞核内对DNA 断裂敏感的蛋白酶，目前其在DN 发病机制中的作用尚未完全阐明。DN 时，肾小球系膜细胞是多种致病因子作用的主要靶细胞，主要表现为肾小球的肥大、细胞外基质的堆积、肾小多聚二磷酸腺苷（ADP ）核糖聚合酶-1（PARP-1）在高糖致大鼠肾脏系膜细胞细胞外基质沉积中...
proteinpost- translationalmodificationenzymesexistinginthemajorityofeukaryoticcells,whilePARP-1wasstudiedastheearliest andmostthoroughone.PARP-1playedanimportantroleintheinductionofcellapoptosisbyhydroquinone.Outlinesof theHQ,PARP-1structureandfunctionaswellasaspectsofPARP-1roleintheinductionofcellapoptosiswere ...
The present study determined that PARP-1 was involved in HQ-induced apoptosis by PARylation of ZO-2. 展开 关键词: hydroquinone ZO-2 PARP-1 poly ADP-ribosylation apoptosis lymphoblastoid cells DOI: 10.3892/mmr.2017.7643 被引量: 3 年份: 2017 ...
(PARP-1) induces neuronal cell death through activation of caspase-independent mechanisms, including release of apoptosis inducing factor (AIF), and microglial activation. Administration of PJ34, a selective PARP-1 inhibitor, reduced cell death of primary cortical neurons exposed to N-Methyl-N'-...