sinensis. Persistent programmed cell death of hepatocytes can induce liver inflammation, activate the differentiation of hepatic stellate cells into myofibroblasts, and eventually cause liver fibrosis. Among these programmed cell death, a poly (ADP-ribose) polymerase-1 (PARP-1) dependent parthanatos ...
Biochem Soc Symp, 1999; 66: 181-203 2.Yu SW, Wang H, Poitras MF et al: Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science, 2002; 297: 259-263R. SwansonC. AlanoW. YingPolish Journal of Radiology...
Gra-B was the first serine protease discovered to cleave PARP-1 during induction of cell death. Gra-B can translocate into cells in both a perforin-dependent and independent manner. Unlike Gra-A, Gra-B shares similar substrate specificity with caspase-3 (i.e. it cleaves after aspartate resid...
Mediation of poly (ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science. 2002;297:259-263. [PubMed] [DOI] 23. Wang ZQ, Auer B, Stingl L, Berghammer H, Haidacher D, Schweiger M, Wagner EF. Mice lacking ADPRT and poly(ADP- ribosyl) ation deve-lop ...
B: Potential routes of nuclear-mitochondrial cross talk in PARP-1–dependent cell death pathways. 1: Extensive PARP-1 activation leads to depletion of NAD+ from the cytosol and accumulation of poly(ADP-ribose) in the nucleus. NAD+ depletion can block glycolysis and thereby block the delivery ...
Targeting AKT suppresses tumor growth through inducing apoptosis, however, during which whether other forms of cell death occurring is poorly understood. The effects of increasing PARP1 dependent cell death (parthanatos) induced by inhibiting AKT on cell
(Fig.3d). Upon exposure to CPT, TOP1 has been reported to be degraded over time in a transcription-dependent manner22,44,45. Hence, the use of transcription inhibitors to analyze the lifespan ofRND1mRNA in CPT-treated cells is likely to sustain the levels of TOP1cc during the time ...
PARP-1 overexpression contributes to Cadmium-induced death in rat proximal tubular cells via parthanatos and the MAPK signalling pathwayParthanatos is a newly discovered form of PARP-1-dependent programmed cell death. It has been reported ... T Luo,Y Yan,Y Qi,... - 《Sci Rep》 被引量: 0...
Background Poly ADP-ribose polymerase-1 (PARP-1),a main DNA repair enzyme,mediates PARP-1-dependent cell death under stress while it maintains genome stabi... 刘宏伟,华宁,于泳浩 - 《国际麻醉学与复苏杂志》 被引量: 0发表: 2013年 治疗神经退行性疾病的多靶点药物分子设计、合成与药理活性评价 第...
The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest Poly(ADP)-ribose polymerase (PARP) inhibitors modify the enzymatic activity of PARP1/2. When certain PARP inhibitors are used either alone or in combinatio... DL Madison,D Stauffer,JR Lundblad - 《Dna Repair》 ...