Parkinson’s disease is caused by the deposition of Lewy body in substantia nigra (part of basal ganglia) leads to the death of dopaminergic neurons and subsequent symptoms from dopamine deficiency. 1.Lewy body意为"路易体",主要是由一种叫做alpha synuclein"α...
Dopamine-receptor-agonists, therapeutic useNewron-PharmaceuticalsParkinson's-disease, treatmentResearch-and-developmentSafinamide, therapeutic useTrial-result-clinical
IMPORTANCE OF THE FIELD: Levodopa (LD) is an efficient drug for patients with Parkinson's disease (PD). Its short half-life supports peaks and troughs. These plasma fluctuations support alternating stimulation of striatal postsynaptic dopamine receptors and thus onset of motor complications. They ...