Parkinson's disease is a neurodegenerative disease caused by the death of neurons, ie, cells critical to the production of dopamine, an important neurotransmitter in the brain. Here, we present a brief review of the dopamine synthetic pathway, binding to the dopamine receptors, and subsequent ...
No abstract is available for this article.doi:10.1111/j.1600-0404.1984.tb02387.xA. LaihinenDepartment of Neurology, University of Turku, Turku, FinlandU. K. RinneDepartment of Neurology, University of Turku, Turku, FinlandJohn Wiley & Sons, Ltd.Acta Neurologica Scandinavica...
It is now generally accepted that the loss of dopaminergic substantia nigra neurons and dopamine deficiency in the corpus striatum play an essential role in the pathophysiology of Parkinson's disease. This was well established by Ehringer and Hornykiewicz (1960) and has subsequently been confirmed ...
Changes of functional connectivity of the motor network in the resting state in Parkinson's disease We used functional MRI (fMRI) and a network model based on graph theory to measure functional connectivity of brain motor network in the resting state in p... Tao,Wu,Liang,Wang,Yi,Chen,......
Cell replacement therapies for neurodegenerative disease have focused on transplantation of the cell types affected by the pathological process. Here we describe an alternative strategy for Parkinson's disease in which dopamine neurons are generated by direct conversion of astrocytes. Using three transcripti...
Parkinson's disease is a movement disorder characterized by degeneration of dopamine-producing neurons. At early stages, pharmacological replacement treatment with dopamine receptor agonists or the dopamine precursor, L-DOPA, can cause symptomatic relief. However, ultimately these treatments are insufficient...
We used two analytic methods (a multichannel coulometric electrode array with high-performance liquid chromatography, and gas chromatography-mass spectrophotometry) to measure CSF dopamine (DA) and its metabolites in mildly affected, unmedicated subjects with Parkinson's disease (PD). The mean (+/- ...
Receptor heteromerization in adenosine A2A receptor signaling: relevance for striatal function and Parkinson's disease. Recently evidence has been presented that adenosine A2A and dopamine D2 receptors form functional heteromeric receptor complexes as demonstrated in human n... K Fuxe,LF Agnati,K Jacob...
Role of dopamine agonists in Parkinson鈥檚 disease: an update At present, dopamine agonists play an important role in antiparkinsonian therapy since they were proved effective in the management of both advanced- and e... U Bonuccelli,N Pavese - 《Expert Review of Neurotherapeutics》 被引量: ...
While supportive of a dopaminergic role in consolidation, this study failed to replicate previous findings on reinforcement learning.DOI: http://dx.doi.org/10.7554/eLife.26801.001 展开 关键词: reward dopamine reinforcement learning Parkinson's disease Human Biological Sciences(General Medicine(General ...