Dopamine agonist monotherapy in Parkinson's disease Levodopa is the gold-standard therapy for Parkinson's disease. However, long-term treatment leads to involuntary movements and response fluctuations which ... CE Clarke,M Guttman - 《Lancet》 被引量: 393发表: 2002年 Dopamine agonist therapy in ...
Parkinson's disease (PD) is characterized by dopaminergic neurodegeneration in the substantia nigra (SN). Transforming growth factor-β1 (TGF-β1) levels increase in patients with PD, although the effects of this increment remain unclear. We have examined the mesostriatal system in adult mice def...
Tetrahydroisoquinolines (TIQs) are intraneuronal, catecholamine-derived alkaloids that have been implicated in the etiology of Parkinson's disease and in a... AJ Nappi,E Vass,MA Collins - 《Biochimica Et Biophysica Acta》 被引量: 18发表: 1999年 Dopamine-Derived Isoquinolines as Dopaminergic Neurot...
we discuss the immune cells present in each region, and how these could interact with dopamine in each compartment described. Finally, the review briefly addresses how changes in these dopamine concentrations could influence immune cell dysfunction in several disease states including Parkinson’s disease...
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease, it affects up to 4% of people aged 65 years or more1. Hallmarks of the disorder are motor symptoms such as tremor, rigidity, bradykinesia and gait disturbances2, which are a result of the selective degeneration ...
AIM: To analyze the correlation between the severity of Parkinson disease (PD) and the distribution of radioactivity uptake of dopamine transporter (DAT) in cerebral bilateral striatum by means of single photon emission computer tomography (SPECT). METHODS: ①Thirty PD patients treated at the Second...
Abnormal dopaminergic function is implicated in diseases and disorders like Parkinson’s disease,3 Alzheimer’s disease,4 schizophrenia,5 addiction,6 bipolar disorder,7 and attention-deficit hyperactivity disorder (ADHD).8 Dopamine signaling also underlies the regulation of movement and plays an important...
18 January 2023 / Accepted: 18 February 2023 / Published online: 27 February 2023 © The Author(s) 2023 Abstract Purpose In routine practice, dopamine transporter (DAT) imaging is frequently used as a diagnostic tool to support the diagnosis of Parkinson's disease or dementia with Lewy ...
the brain. The Franklin Institute suggests that chronic stress and depletion of dopamine in exchange for hormone flooding creates the internal body environment perfect for Alzheimer's disease, Parkinson's disease, heart disease and cancer in addition to numerous autoimmune disorders that can be ...
Post hoc analysis revealed that there was a significantly shorter latency to attack in the stressed Tph2+/− group than in either the non-stressed Tph2+/− or the stressed Tph2+/+ mice (both p < 0.01, Sidak's test). A significant day × genotype interaction, independent of predator...