近日,荷兰的生物技术初创公司Pan Cancer T在知名肿瘤学杂志《Cancer Discovery》上发表了一篇题为“TCR-engineered T-cells directed against Ropporin-1 constitute a safe and effective treatment for triple-negative breast cancer(靶向Ropporin-1 的 TCR -T 细胞疗法是治疗三阴性乳腺癌安全有效的方法)”的文章。
The present invention provides novel pan-cancer T cell exhaustion regulators. CXCR6 expressed in CD8+ T cells was specifically identified as regulating anti-tumor immunity. Modulating CXCR6-CXCL16 interaction is useful in modulating anti-tumor immunity. The identified genes may be modulated in T ...
T cells have benefitedmany cancer patients, but the clinical efficacyvaries greatly among different cancer types.Tumor-infiltrating T cells often enter a dys-functional state, widely known as T cell exhaus-tion, and the antitumor functions of effectorT cells are regulated by multiple factors, in-...
cDNA的大小为200-500 bp,可以直接NGS而无需片段化。数据处理后,作者获得了2290个细胞核(293T:细胞核1122,中位数基因4729;3T3:细胞核1150,中位数基因3605),不超过0.8%的细胞双胞率(图1d,e)。与基于poly(A)的10X Chromium不同,snHH-seq在基因体上显示出均匀的覆盖,类似于VASA-seq[18](图1f)。 作者接下来...
For T cells, we computed a signature score based on the average normalized values of five canonical markers (LCK, CD3E, CD3D, CD3G, CD2). For cytotoxic T cells, we computed a signature score based on canonical markers CD8A and CD8B. For T helper and regulatory T cells, we considered ...
Similarly, if the fraction of tumour cells in the cancer sample is low through stromal contamination, the detection of driver mutations can be impaired. Most tumours with no known drivers had an average power to detect mutations close to 100%; however, a few had power in the 70–90% range...
CD8 + T cells play a pivotal role in anti-tumor immunity, yet the mechanisms underlying the interaction between iCAFs and CD8 + T cells remain elusive. Ligands from iCAFs that bind to CD8 + T cells were enriched in various T cell-related functions, including migration, activat...
T cells by promoting H+accumulation and sustaining a low pH within the TME and acidic TME can enhance the suppression of antitumor immunity, thereby reducing the effectiveness of immunotherapy [66]. Under the circumstance of lactic acidosis, monocytes could differentiate into either dendritic cells ...
tumor-infiltrating myeloid cells, single-cell transcriptional atlas, pan-cancer analysis, heterogeneity, mast cells, cDCs, TAMs 肿瘤浸润性髓系细胞,单细胞转录图谱,泛癌分析,异质性,肥大细胞,cDCs,TAMs 论文简要 本研究通过全癌分析,构建了肿瘤浸润性髓系细胞的单细胞转录图谱,揭示了肿瘤浸润性髓系细胞的异质...
Low-dose gemcitabine depletes regulatory T cells and improves survival in the orthotopic Panc02 model of pancreatic cancer. Int J Cancer 2013 ; 133:98 - 107; http://dx.doi.org/ 10.1002/ijc.27990 ; PMID: 23233419Shevchenko I, Karakhanova S, Soltek S, Link J, Bayry J, Werner J, et ...