Induction of anergic or regulatory tumor-specific CD4(+) T cells in the tumor-draining lymph node. Nat Commun, 9(1), 0. doi:10.1038/s41467-018-04524-x 8. Atsushi, Tanaka., Shimon, Sakaguchi.(2016). Regulatory T cells in cancer ...
Cancer immunology and immunotherapy are driving forces of research and development in oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent progress highlights the importance of CD4+ T cells, corresponding to the long-known fac
Cancer immunology and immunotherapy are driving forces of research and development in oncology, mostly focusing on CD8+T cells and the tumor microenvironment. Recent progress highlights the importance of CD4+T cells, corresponding to the long-known fact that CD4+T cells are central players and coord...
但最新的研究发现,CD4+T细胞竟然能够找到细胞毒性T细胞无法识别的隐藏的癌细胞并杀死这些癌细胞【1】。 2023年6月14日,德国科学家在Nature杂志发表了题为“CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours”的文章...
Cancer immunotherapy aims to promote the activity of cytotoxic T lymphocytes (CTLs) within a tumour, assist the priming of tumour-specific CTLs in lymphoid organs and establish efficient and durable antitumour immunity. During priming, help signals are relayed from CD4+ T cells to CD8+ T cells...
(Cytotoxic CD4+ T cells in cancer: Expanding the immune effector toolbox)》的解析,该综述于2021年12月发表于Immunity(IF:43.474)。 综述背景: T细胞是免疫系统对抗癌症的重要效应器,分为CD8+T细胞和CD4+T细胞。通常只有CD8+T细胞被认为具有消灭肿瘤的作用,但临床研究已发现肿瘤中的CD4+T细胞也具有细胞毒性。
Treg细胞在生理状态下主要通过抑制其他免疫细胞的活性,维持免疫平衡,防止过度免疫反应;而在肿瘤组织中,则表现出促进肿瘤生长的作用。CD4+ T细胞在肿瘤微环境中的作用十分多样,下面小编首先通过一篇今年发表在Nature cancer上,篇名为:CD4+ T cells in cancer的综述,来系统认识一下肿瘤组织中CD4+ T细胞的千人千面。
Zanetti M. Tapping CD4T cells for cancer immunotherapy: the choice of personalized genomics. J Immunol. 2015;194:2049-56. doi:10.4049/ jimmunol.1402669. PMID:25710958.Zanetti M. Tapping CD4 T cells for cancer immunotherapy: the choice of personalized genomics. J Immunol. 2015;194(5):2049-...
(Cytotoxic CD4+ T cells in cancer: Expanding the immune effector toolbox)》的解析,该综述于2021年12月发表于Immunity(IF:43.474)。 综述背景: T细胞是免疫系统对抗癌症的重要效应器,分为CD8+T细胞和CD4+T细胞。通常只有CD8+T细胞被认为具有消灭肿瘤的作用,但临床研究已发现肿瘤中的CD4+T细胞也具有细胞毒性。
(Cytotoxic CD4+ T cells in cancer: Expanding the immune effector toolbox)》的解析,该综述于2021年12月发表于Immunity(IF:43.474)。 综述背景: T细胞是免疫系统对抗癌症的重要效应器,分为CD8+T细胞和CD4+T细胞。通常只有CD8+T细胞被认为具有消灭肿瘤的作用,但临床研究已发现肿瘤中的CD4+T细胞也具有细胞毒性。