参考资料: [1] Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition [2] White blood cells and their role in the brain [3] New role for white blood cells in the developing brain [4] Cell丨大脑中...
[7]Froidure A, Shen C, Gras D, et al. Myeloid dendritic cells are primed in allergic asthma for thymic stromal lymphopoietin-mediated induction of Th2 and Th9 responses. Allergy, 2014, 69(8): 1068-1076 [8]Zhu J, Paul W E. CD4 T cells: fates, functions, and faults. Blood, 2008,...
Osum KC, Jenkins MK. Toward a general model of CD4+ T cell subset specification and memory cell formation. Immunity. 2023;56(3):475-484. doi:10.1016/j.immuni.2023.02.010 Oh DY, Fong L. Cytotoxic CD4+ T cells in cancer: Expanding the immune effector toolbox. Immunity. 2021;54(12):27...
近日,这项研究的研究结果发表在《Nature Methods》上,题为“Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4 T cells allows complex functional analyses+”。 https://doi.org/10.1038/s41592-021-01328-8 “静息的CD4+ T细胞不会分裂分化,几乎不适合所有的基因...
CD4 T细胞通常也称为辅助性T淋巴细胞(CD4 Helper T Cells),它的成长经历和CD8 T细胞一样,也是在胸腺由淋巴祖细胞经过克隆选择/双阴/双阳等层层筛选分化而成。 与CD8 T细胞活化需要MHCI-抗原复合体不同,CD4 T细胞活化第一信号来自MHCII-抗原复合体。
[6]Martinorozco N., et al., (2009) T Helper 17 cells promote cytotoxic T tell activation in tumor immunity [J].Immunity,31(5):787-798. 开放转载 欢迎“授权”转载 欢迎转发到朋友圈和微信群。 巨噬细胞,人类免疫系统的精灵 相关科普:
2、磁珠阴选Naïve CD4 T cells;如MojoSort™ Human CD4 Naïve T Cell Isolation Kit; 02. CD4+细胞极化Th2 1、用anti-human CD3 ,clone OKT3 (10µg/ml)包被24孔板,4℃ 过夜孵育,然后用无菌PBS洗涤3次。 2、以5 × 10^6 cell/well密度接种于24孔培养板,加入anti-human CD28, clone CD...
近日，来自美国哈佛医学院马萨诸塞总医院的Shadmehr Demehri研究团队在Cell上发表题为Cytotoxic CD4+ T cells eliminate senescent cells by targeting cytomegalovirus antigen 的文章，发现在衰老人群中，衰老的成纤维细胞数目并不与年龄相关，这是由于衰老细胞的数目由细胞毒性CD4+ T细胞控制，衰老的成纤维细胞表达HLA-...
近日，由香港大学生物医学学院宁珖圣、香港大学玛丽医院李智豪和陈俊明领衔的研究团队，在著名期刊《细胞·代谢》上发表一项重磅研究成果，为高血糖再添一“毒”。他们发现，高血糖会导致CD4阳性T细胞氧化应激升高和脂质异常积累，促进脂质过氧化，损害了CD4阳性T细胞往辅助性T细胞1（Th1）分化，而Th1恰恰是抗病毒免疫的...
CD4-positive T cells are a subtype of lymphocyte. They are MHC class II-restricted and are important mediators of adaptive immunity. These cells are involved in both the induction and the restraint of most immunological functions. A key element in the profound immunosuppression seen in HIV infecti...