2023年6月《Nature Immunology》杂志发表了一篇题为“Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors”的文章,研究团队通过MHC-II类缺陷型鳞状细胞癌肿瘤模型(SCC VI...
基线特征差异:与非存活组相比,存活组患者年龄更低(64.4岁 vs 更高龄),且严重病例更易出现凝血功能障碍和炎症指标升高。 T细胞亚群失衡:SFTS患者DPT细胞比例显著降低,而DNT细胞比例较健康对照升高2.3倍,且在重症和死亡病例中进一步增加。 临床相关性:DNT细胞比例与病毒载量(r=0.62)、凝血时间延长(APTT r=0.58)及炎...
CD8 T Cells Is Influenced by CD4 T Cells 1Northrop, John KThomas, Rajan MWells, Andrew DShen, Hao
此外,还包括辅助B细胞的卵泡辅助T(TFH)细胞、促炎的TH17细胞亚群以及调节性T细胞(TReg),Treg对于避免过度旺盛的免疫反应和相关的免疫病理学至关重要。 CD4+T细胞是抗病毒免疫的协调器、调节器和直接效应器。CD4+T细胞可以帮助B细胞产生更强、寿命更长的抗体反应;CD4+T细胞在初次免疫反应期间可以最大限度地扩大CD8+...
一、CD8+ T提取：准备buffer:2.5% BSA PBS 加10mM EDTA 1.接上一步，计数PBMC，取10e7个细胞，...
During chronic infection, effector CD4+T cells support the maintenance of functional CD8+T cells through secretion of IL-21, whereas TRegcells dampen the CD8+T cell response through suppression of DCs. Abstract Following infection, T cells differentiate into a heterogeneous population of effector T ...
CD4 T cells regulate CD8 T cell responses following CNS infection. Peripheral expansion of virus-specific CD8 T cells was impaired when CD4 T cells were ablated prior to infection but not at 4 days postinfection. Delayed CD4 T cell depletion abrogated CD4 T cell recruitment to the CNS but...
Tissue-resident memory T cells (TRM cells) provide rapid and superior control of localized infections. While the transcription factor Runx3 is a critical regulator of CD8+ T cell tissue residency, its expression is repressed in CD4+ T cells. Here, we show that, as a direct consequence of th...
自身免疫性疾病:胞内自身抗原抗体Vs胞外自身抗原抗体 自身免疫性疾病药物开发新思维 参考文献 D’Acquisto F, Crompton T (2011) CD3+CD4-CD8- (double negative) T cells: saviours or villains of the immune response? Biochem Phar...
"单核细胞源性细胞优化CD4+ T辅助1型和CD8+ T效应分化"部分通过CCR2抗体处理证实,MoDCs虽然不影响初始T细胞激活,但对Th1效应分化和CTL效应分化至关重要。抗体处理组中,PADRE特异性CD4+ T细胞的SLAM+Tbet+ Th1表型和IFNγ产生能力显著降低,HPV E7特异性CD8+ T细胞的KLRG1+CX3CR1+效应表型也明显减少。 研究还发...