P53 (protein) Tumor protein p53 (Li-Fraumeni syndrome) PDB rendering based on 1TUP. Available structures: 1a1u, 1aie, 1c26, 1gzh, 1hs5, 1kzy, 1olg, 1olh, 1pes,
利用RCSB PBD(https://www.rcsb.org/)数据库,检索到Homo sapiens的Skp2晶体结构,选择Skp2(PDB 2C9W)蛋白作为分子对接的晶体结构。利用Maestro软件的Protein Preparation模块对Skp2蛋白晶体结构进行预处理,残基修复、结构校正、氢键优化...
Phosphoprotein p53 Transformation-related protein 53 (TRP53) Tumor suppressor p53功能p53蛋白在避免癌症發生機制上扮演重要的角色,例如,細胞凋亡 (apoptosis) 、基因組穩定性 (genetic stability) 、抑制血管新生(angiogenesis)。 p53蛋白通過下列之機構達成避免癌症發生:當...
MK-8242分子具有高MW,高clogp,较高的推荐剂量(2期剂量为每天0.8 g);默克公司最初通过高通量筛选新的骨架分子以期望得到分子量低、剂量也低的HDM2-P53抑制剂。 图2 hit的优化过程及2和HDM2蛋白的共晶 (PDB 7NA1) 通过高通量筛选得到化合物1,这是一个分子...
We used Phyre238 to predict the secondary protein structure of p53β and p53β-stop-lost. The oligomerization domains of a p53α dimer (PDB 1SAE39) each consist of a β-sheet followed by an α-helix of ~5.5 turns, orientated antiparallel (Fig. 5a, left panel)40,41. The C-terminal...
PD-L1: programmed death-ligand 1; PI3K: phosphoinositide 3-kinase; AKT: protein kinase B; mTOR: the mammalian target of rapamycin; eIF4E: eukaryotic translation initiation factor 4 epsilon; PFTα: Pifithrin-α HBr; DCs: dendritic cells; PDB: the Protein Data Bank; TME: tumor microenvironment;...
利用RCSB PBD(https://www.rcsb.org/)数据库,检索到Homo sapiens的Skp2晶体结构,选择Skp2(PDB 2C9W)蛋白作为分子对接的晶体结构。利用Maestro软件的Protein Preparation模块对Skp2蛋白晶体结构进行预处理,残基修复、结构校正、氢键优化、溶剂去除和能量最小化,将处理后的蛋白结构选为受体,使用Grid Generation模块对受...
What is the true extent of 14-3-3 protein involvement in p53 regulation and tumour suppression? Can the currently putative links between 14-3-3 activity and p53 function be firmly established? What is the basis of 14-3-3 isoform-specific function and can this be harnessed for selective targ...
Hence, the basic concept underlying this study is the change in flexibility or rigidity of the protein. It was found that stable variant T-p53C (PDB-ID: 1uol) that is structurally and functionally very close to wild-type p53 is the most rigid structure and each single carcinogenic mutation ...
实验方法:利用生物分子分析的微量热泳(mst)技术,分析了化合物ⅰ与p53蛋白dna结合区(pdb编号为4lof)。 实验原理:微量热泳(mst)是一种生物分子的分析技术,是粒子在微观的温度梯度中的定向运动。生物分子结构/构象变化引起的水化层变化导致的沿温度梯度运动的相对变化可以确定亲和力。