p53腫瘤蛋白p53 PDB基於1TUP的渲染:P53與DNA結合[1] 有效結構 PDB 直系同源檢索:PDBe, RCSB PDB查詢代碼列表 1A1U、 1AIE、 1C26、 1DT7、 1GZH、 1H26、 1HS5、 1JSP、 1KZY、 1MA3、 1OLG、 1OLH、 1PES、 1PET、 1SAE、 1SAF、 1SAK、 1SAL、 1TSR、 1TUP、 1UOL、 1XQH、 1YC5...
Neither p53 nor Ki67 appears to have a prognostic role to play in PDB.doi:10.1006/gyno.2002.6629P.E. EllisL.F. Wong Te FongK.J. RolfeJ.C. CrowW.M.N. ReidT. DavidsonA.B. MacLeanC.W. PerrettElsevier Inc.Gynecologic Oncology
A recent apo-16E6 structure was deposited to the PDB which has an elongated and distorted alpha-helical linker between the N- and C-terminal lobes; however, the publication describing this structure is yet to be released (PDB ID no 7UAJ). The E6AP LXXLL peptide occupies and stabilizes the...
P53 (protein) Tumor protein p53 (Li-Fraumeni syndrome) PDB rendering based on 1TUP. Available structures: 1a1u, 1aie, 1c26, 1gzh, 1hs5, 1kzy, 1olg, 1olh, 1pes,
P53肿瘤抑制蛋白 英文标题：p53 Tumor Suppressor 作者：David Goodsell 原著日期：2002-07 译者：李玉明（上海兽医研究所）翻译日期：2014-10-10 原文链接：10.2210/rcsb_pdb/mom_2002_7 关键词：肿瘤抑制蛋白、癌症、转录调节、转录因子、致癌作用 细胞的守护者 我们的细胞会面对许多危险，比如，化学药品，病毒和...
aSummary of the 14-3-3 PPIs involved in upstream p53 regulation.bCrystal structure of dimeric 14-3-3σ. For one monomer, the canonical phosphate binding site within the amphipathic groove (cyan) and the 14-3-3σ-specific secondary binding site (orange). PDB: 1YWT. ...
利用RCSB PBD(https://www.rcsb.org/)数据库,检索到Homo sapiens的Skp2晶体结构,选择Skp2(PDB 2C9W)蛋白作为分子对接的晶体结构。利用Maestro软件的Protein Preparation模块对Skp2蛋白晶体结构进行预处理,残基修复、结构校正、氢键优化...
PDBID 3KMD. A Structural diagram of a p53 tetramer. Each p53 monomer is shown in a different color, and DNA is in gray. B The same diagram but from a different angle, showing where the four interacting TDs would be in relation to the DBDs and the DNA Full size image The TD is hig...
To accurately reflect the interaction between the protein and the compound, we found the crystal structure of the P53 protein (PDB code: 4AGL11 and 6FJ532) from the research collaboration for structural bioinformatics (RCSB). The molecular docking was performed using Schrödinger version 2015-433...
图2 hit的优化过程及2和HDM2蛋白的共晶 (PDB 7NA1) 通过高通量筛选得到化合物1,这是一个分子量低、带嘌呤骨架的小分子化合物,对hit的优化集中在嘌呤母核的C6、N7和C8上,环己亚甲基替换为对氯苄基、间苯基改为苯并噻吩、NH的α位碳引入手性甲基;最终活性...