We adjusted a linear mixed model to relative nascent mRNA expression to decide whether gene expression can be explained by the fixed-effect of the experimental condition (either the effect of Nutlin-3a over time or degradation of RAD21), or by a random effect. p-values correspond to the reje...
and Stilgenbauer, S., Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53- p21 dysfunction, and miR34a in a prospective clinical trial. Blood 2009 114: 2589-2597. http://dx.doi....
Alternatively, genes encoding other components of the p53 pathway can exhibit mutations (Vogelstein et al., 2000, Vousden and Lu, 2002). While cell-cycle arrest depends on the ability of p53 to induce the transcription of target genes such as the CDK inhibitor p21/waf1 (el-Deiry et al....
Death of the Bcl-2 overexpressing B cells can be explained by the prominent induction of the extrinsic apoptotic pathway, with an active role of the neoplastic microenvironnement for the expression of death receptor ligands and the clearance of the apoptotic cells. These insights have implications ...
in DLD1 cells SAHA triggered a low level of autophagy despite promoting a strong decrease in mutp53 level, and autophagy inhibition did not change either mutp53 levels or sensitivity to this drug. We conclude that autophagy can be...
Publishing models and article dates explained Published online: 15 Nov 2010 Article Views: 20 Article usage statistics combine cumulative total PDF downloads and full-text HTML views from publication date (but no earlier than 25 Jun 2011, launch date of this website) to 16 May 2015. Article ...
p53-mediated-mitochondrial cell death pathway was examined in our PFT-α treatment paradigm. Western blot revealed a significant increase in the Bax to Bcl-2 ratio and apoptosis-inducing factor (AIF) expression, which are both an index of mitochondrial cell death pathway19,20, along with increase...
pathway. 49 , 52 many of the tissue changes seen in pterygia can be explained by this mechanism. 13 , 49 , 52 - 65 first, in the migrating limbus of pterygium cells, tgf-β production occurs, resulting in a decreased number of cell layers (average, 3-4 layers). 49 , 52 - 55 ...
The recently discovered p53-dependent DNA damage tolerance (DDT) pathway relies on its biochemical activities in DNA-binding, oligomerization, as well as complex formation with the translesion synthesis (TLS) polymerase iota (POLι). These p53-POLι comp
Thus, the p53 signalling pathway in adipocytes might represent an interesting target to ameliorate the effectiveness of dietary weight loss interventions. Underscoring the therapeutic utility of p53 in obesity interventions, our data propose a translational relevance of p53 in the response to weight-...