近日,华中科技大学基础医学院生物化学与分子生物学系研究生李能同学和团队成员在国际期刊The Journal of Biological Chemistry发表了题为“在肝癌中P53-P21-RB1轴通过USP1促进BRD4蛋白的降解”(The P53-P21-RB1 pathway promotes BRD4 degradation ...
P53-P21-Rb信号通路在缺血再灌注损伤后期肾小管上皮细胞衰老中作用.pdf 关闭预览 想预览更多内容,点击免费在线预览全文 免费在线预览全文 论善JMedRes,Dec2008,Vo1.37No.12 减少 ,而 Western—Blot条带光密度扫描也显示其表 nalingpathwayactivated byosteopontin inhibitsneointimalfomr ation 达的蛋白减少 ,说明 ...
Together, these results demonstrate the existence of complex links between different signaling cascades in stressed hMESC, implicating ERK, p38, and JNK in regulation of premature senescence via the p53/p21/Rb pathway.doi:10.1134/S1990519X16030056Deryabin, P. I....
p21 WAF1/CIP1抑制CDKs，通过引起Rb（视网膜母细胞瘤）的低磷酸化，阻止E2F的释放，抑制G1到S和G2...
目前对p53、p21、Rb基因及其蛋白产物的研究手段主要有免疫组织化学、PCR-SSCP和序列分析等,其中以前者使用最广泛。免疫组化已经被证实是检测p53、p21和pRb异常表达的可靠手段[107,113,126,127],因而本实验选取了与临床结合紧密、简便、经济的免疫组化作为实验方法。
p53-dependent transcriptional repression is indirect. The reduced expression of the many regulators leads to cell cycle arrest. Examination of the p53-p21-RB targets and genes controlled by the related p53-p21-DREAM signaling pathway reveals that there is a large overlap of the two groups. ...
正常情况下,细胞周期蛋白D(cyclin D)与CDK4/6形成活性激酶复合物,磷酸化视网膜母细胞瘤相关蛋白(Rb)以调节G1到S期的过渡,但临床、动物模型和体外研究结果表明CDK4/6抑制剂的作用机制非常复杂,例如,RB1突变引发对CDK4/6i的耐药...
p53-Rb signaling pathway is involved in tubular cell senescence in renal ischemia/reperfusion injury Objective: To investigate the course of tubular cell senescence and expressions of p53, p21, and Rb during the late phase of ischemia/reperfusion (IRI) in ... K Li,X Du,Y He,... - 《...
A stress-induced miR-31–CLOCK–ERK pathway is a key driver and therapeutic target for skin aging Main In mammals, the skin is the largest organ...genesp21,p27,Pai1, andTert1are increased in the skin ofp53TSD/−mice, compared with those in p53+/−mice.n=3. Values represent means±...
pathway (sterol synthesis pathway) and lower cholesterol levels. Blocking the 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CR) prevents the ...P21, andMDM2increased in the leukemic bone marrow and four patients achieved remission [117]. Two more studies are currently recruiting participants ...