Garner E, Raj K (2008) Protective mechanisms of p53-p21-pRb proteins against DNA damage-induced cell death. Cell Cycle 7(3):277–282. PMID: 18235223Garner E, Raj K. Protective mechanisms of p53-p21-pRb proteins against DNA damage-induced cell death. Cell Cycle. 2008;7:277–82....
本文全文图片 头颈部鳞状细胞癌中G1/S期不同的信号通路示意图 图中,蓝线表示p53、p21、p16、cyclin D和pRB蛋白在信号通路中的直接作用;灰线表示HPV、E6和E7蛋白对细胞周期的间接影响。CDK4/6:周期蛋白依赖性激酶4/6;pRB:视网膜母细胞瘤易感基因蛋白;HPV:人乳头瘤病毒。
pRb, P53 and P21Cip1are critical regulators of the cell cycle that have all been involved in the antiproliferative effect of TGFβ in various systems. However, the fact that pRb phosphorylation is the main target of the regulation G1/S progression by P53 and P21Cip1 makes it difficult to ...
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Pinto AE, Andre S, Laranjeira C, Soares J: Correlations of cell cycle regulators (p53, p21, pRb and mdm2) and c-erbB-2 with biological markers of proliferation and overall survival in breast cancer. Pathology 2005, 37: 45–50.Pinto AE, Andre S, Laranjeira C, Soares J: Correlations ...
Arbelaez, Santiago; Munoz, Jose; Vigues, Francesc; Garcia Del Muro, Xavier; Condom, Enric; Serrallach, Narcis, 2002: Predictive value of p53, pRB and p21 in the bladder TCC treated with neoadjuvant chemotherapydoi:10.1016/S1569-9056(02)80156-7Santiago Arbeláez...
Feng et al., "Cellular senescence regulated by SWI/SNF complex subunits through p53/p21 and p16/pRB pathway," The International Journal of Biochemistry & Cell Biology, vol. 90, pp. 29-37, 2017.He L, Chen Y, Feng J, Sun W, Li S, Ou M and Tang L: Cellular senescence regulated by...
M. Nesland.Protein expression of p53, p21 (WAF1/CIP1), bcl-2, Bax, cyclin D1 and pRb in human colon carcinomas[J]. Virchows Archiv .2000(3)Bukholm I K,Nesland J M. Protein expression of p53,p21(WAF1/CIP1),bcl-2,Bax,cyclin D1 and pRb in human colon carcinomas[J].Virchows...
目的探讨p53, p21/WAF1和pRb的异常表达在T1G3膀胱癌预后判断中的价值. 方法对47例T1G3膀胱癌患者进行术后随访,采用p53, p21/WAF1和pRb单克隆抗体对手术标本行免疫组化染色.将肿瘤进展情况与染色结果和与预后相关的临床指标进行分析. 结果 39例手术保留膀胱的患者总进展率为59%,其中9例发生远处转移.8例行膀胱...
Yang G,Zhang Z,Liao J,Seril D,Wang L,Goldstein S,Yang CS.Immunohistochemical studies on Waf1p21, p16, pRb and p53 in human esophageal carcinomas and neighboring epithelia from a high-risk area in northern China. International Journal of Cancer . 1997...