p53endometrial stem cellsoxidative stresssignaling pathwaysHuman endometrium-derived mesenchymal stem cells (hMESC) under the sublethal oxidative stress induced by H 2 O 2 activate both the p53/p21/Rb and p38/MAPKAPK-2 pathways that are responsible for the induction of hMESC premature senescence (...
Objectives The objectives of our study were (1) to characterize the expression of p21 and p53 proteins in advanced stage prostate cancer, (2) to determine the relationship between p53 and p21 protein expressions, and (3) to relate p53 and p21 expression to clinical outcome after androgen ablati...
The intersection between DNA damage response and cell death pathways. Exp Oncol 2012; 34: 243–254. CAS PubMed PubMed Central Google Scholar Wang X, Simpson ER, Brown KA . p53: Protection against tumor growth beyond effects on cell cycle and apoptosis. Cancer Res 2015; 75: 5001–5007. ...
Similarly, there was no significant relationship between cyclin E expression and cyclin E-Cdk2 activity. Fractionation of whole cell lysates by gel filtration chromatography revealed that approximately 90% of the cyclin E protein was present in inactive complexes containing the CDK inhibitors p21 and ...
2. The Relationship between the Development of Bladder Cancer and Nutrients Biological plausibility supports the potential influence of dietary factors on the likelihood of bladder cancer development, as both beneficial and harmful elements of a diet are excreted through the urinary tract and directly in...
Objective: To investigate the roles and relationships among ERK pathway, P53/P21 and CDK5/P35 during neuronal differentiation using a differentiative model of PC12 cells induced by NGF. 目的:利用NGF诱导的PC12细胞分化模型,探讨ERK通路、P53/P21蛋白和CDK5/P35蛋白在神经元分化过程中的可能作用及相互关系...
Relationship of family cancer history to the expression of p53, p21WAF-1, HER-2/neu, and K-ras mutation in pancreatic adenocarcinoma expression of p53 and p21 WAF in pancreatic tumors, but show no relationship to the expression of HER-2 / neuor to the prevalence of K- ras ... ST Derg...
No significant association was found between either AI or MI and prognosis. p53, p21, mdm2, and bcl-2 positivity were detected in 65.4%, 53.8%, 65.4%, and 34.6% of cases, respectively. mdm2 was significantly associated with p53 ( p <0.03) and p21 ( p <0.04) expression and p53 ...
While the regulation of p110δ activity is related to cell growth, the activity of p110γ involves the regulation of cell survival [78–80]. An increased resistance to cell death was also observed as a result of the simultaneous inhibition of p53 and activation of nuclear factor κB (NF-κ...
Hence, we sought to determine whether this protein is abnormally expressed during betel- and tobacco-related oral oncogenesis. The aim was to determine whether a correlation exists between the expression profile of p21 and clinicopathological parameters of the patients, as well as with their p53 ...