Among the 4 molecular subgroups of endometrial carcinoma, the p53 abnormal (copy number high) subgroup has the worst prognosis; however, the histologic characteristics of this subgroup are not well established. Also, it is not well established whether low-grade tumors can belong to the p53 ...
参考文献: Jamieson, Amy et al. “Clinical Behavior and Molecular Landscape of Stage I p53-abnormal Low-Grade Endometrioid Endometrial Carcinomas.”Clinical cancer research : an official journal of the American Association for Cancer Research, 10.1158/1078-0432.CCR-23-1397. 29 Sep. 2023,doi:10.115...
参考文献: Jamieson, Amy et al. “Clinical Behavior and Molecular Landscape of Stage I p53-abnormal Low-Grade Endometrioid Endometrial Carcinomas.”Clinical cancer research : an official journal of the American Association ...
参考文献: Jamieson, Amy et al. “Clinical Behavior and Molecular Landscape of Stage I p53-abnormal Low-Grade Endometrioid Endometrial Carcinomas.”Clinical cancer research : an official journal of the American Association for Cancer Research, 10.1158/1078-0432.CCR-23-1397. 29 Sep. 2023,doi:10.115...
Jamieson, Amy et al. “Clinical Behavior and Molecular Landscape of Stage I p53-abnormal Low-Grade Endometrioid Endometrial Carcinomas.”Clinical cancer research : an official journal of the American Association for Cancer Research, 10.1158/1078-0432.CCR-23-1397. 29 Sep. 2023,doi:10.1158/1078-043...
Jamieson, Amy et al. “Clinical Behavior and Molecular Landscape of Stage I p53-abnormal Low-Grade Endometrioid Endometrial Carcinomas.”Clinical cancer research : an official journal of the American Association for Cancer Research, 10.1158/1078-0432.CCR-23-1397. 29 Sep. 2023,doi:10.1158/1078-043...
--p53异常过表达(p53 abnormal overexpression, OE):通常是TP53的错义突变,突变位点通常在DBD的中心位置 --p53异常完全缺失(p53 abnormal complete absence, CA):通常是TP53发生无义、移码、剪接或缺失突变,导致p53免疫组化所用抗体无法识别的突变p53的抗原表位,表现为IHC阴性 --p53异常胞浆着色(p53 abnormal cytopl...
Fibrosis is a reparative and progressive process characterized by abnormal extracellular matrix deposition, contributing to organ dysfunction in chronic diseases. The tumor suppressor p53 (p53), known for its regulatory roles in cell proliferation, apoptosis, aging, and metabolism across diverse tissues, ...
Editorial comments: Detection of abnormal p53 protein levels in cytology specimens: Present and future applicationsP53 PROTEINFINE-NEEDLE ASPIRATEIMMUNOCYTOCHEMISTRYBREAST CANCER.doi:10.1002/dc.2840130210Ann ThorJohn Wiley & Sons, Ltd.Diagnostic Cytopathology...
G. Order and disorder: abnormal 3D chromatin organization in human disease. Brief. Funct. Genom. 19, 128–138 (2020). Article Google Scholar Okhovat, M. et al. TAD evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function. Nat Commun 14,...