Abnormalities of the p53 tumor suppressor gene are the single most common molecular abnormality seen in human cancer, being found in more than 50% of malignancies. Considerable evidence indicates that the product of this gene has critical roles in coordinating the response of cells to a diverse ...
5q-综合征是骨髓增生异常综合征(MDS)的特殊亚型,该病患者的临床表现以贫血为主,血小板计数可正常或增高,骨髓原始细胞比例<5%,预后较好。随着对5q-综合征研究的进展,其发病机制逐渐被揭示。位于5号染色体长臂(5q)的 CSNK1 A1、 RPS14、 EGR1等致病基因单倍剂量不足,是引起该病不同临床表型的主要分子机制,其中...
1994 . High frequency of p53 abnormality in laryngeal cancers of heavy smokers and its relation to human papillomavirus infection . Jpn J Cancer Res 85 : 1087 – 1093 .SuzukiT, Shidara K, Hara F, NakajimaT. High frequency of p53 abnormality in laryngeal cancers of heavy smokers and its ...
Novel patterns of p53 abnormality in breast cancer from Taiwan: experience from a low-incidence area. Br J Cancer. 1997;75:746–51.Lou MA, et al., Novel patterns of p53 abnormality in breast cancer from Taiwan: experience from a low incidence area. Br J Cancer 1997; 75:746-51....
A recent systematic review identified 168 reports on p53 abnormality and outcome58, although many of these were based on the use of IHC. For studies that used mutation analysis, the increased risk of death associated with p53 mutation in the overall group was 1.31 (95% CI: 1.19–1.45) and...
Novel patterns of p53 abnormality in breast cancer from Taiwan: experience from a low-incidence area. Br J Cancer. 1997;75:746–51. 39. Melhem-Bertrandt A, Bojadzieva J, Ready KJ, Obeid E, Liu DD, Gutierrez-Barrera AM, et al. Early onset HER2-positive breast cancer is associated ...
Mutations in p73 are uncommon in human neoplasia, overexpression of p73 being the most frequent abnormality of p73. A subset of cases in breast cancer overexpress p73, and in one study this was associated with lymph node metastasis, vascular invasion and high-grade malignancy [48]. Analysis of...
33.smithaeetal.(2015)csnk1a1mutationsandisolateddel(5q)abnormalityinmyelodysplasticsyndrome:aretrospectivemutationalanalysis.lancethaematol2(5):e212-21. 34.saftletal.(2014)p53proteinexpressionindependentlypredictsoutcomeinpatientswithlower-riskmyelodysplasticsyndromeswithdel(5q).haematologica99(6):1041-9. ...
examinotion.It was found that the deletion and mutation rate of p53 gene in basal cell carcinoma was 42% (5/12),whereas no deletion and mutation were observed in 5 normal tissue specimens.Our results indicate that the abnormality of p53 gene is an important event in carcinogenesis and ...
It is noteworthy that alterations such as a CK (defined by at least three unrelated cytogenetic abnormalities), monosomal karyotype (MK) (defined by at least two autosomal monosomies, or one autosomal monosomy associated with at least one structural abnormality), -5 or del(5q), -7, t(6;...