Endometrial cancer is classified into four molecular subtypes of which the p53 abnormal variant is biologically aggressive. Programmed cell death protein 1 (PD-1) is a cell surface receptor and a vital inhibitor of the immune response. Programmed death ligand 1 (PD-L1) is a trans-membrane co-...
参考文献: Jamieson, Amy et al. “Clinical Behavior and Molecular Landscape of Stage I p53-abnormal Low-Grade Endometrioid Endometrial Carcinomas.”Clinical cancer research : an official journal of the American Association for Cancer Research, 10.1158/1078-0432.CCR-23-1397. 29 Sep. 2023,doi:10.115...
参考文献: Jamieson, Amy et al. “Clinical Behavior and Molecular Landscape of Stage I p53-abnormal Low-Grade Endometrioid Endometrial Carcinomas.”Clinical cancer research : an official journal of the American Association ...
参考文献: Jamieson, Amy et al. “Clinical Behavior and Molecular Landscape of Stage I p53-abnormal Low-Grade Endometrioid Endometrial Carcinomas.”Clinical cancer research : an official journal of the American Association for Cancer Research, 10.1158/1078-0432.CCR-23-1397. 29 Sep. 2023,doi:10.115...
Endometrial cancer is classified into four molecular subtypes of which the p53 abnormal variant is biologically aggressive. Programmed cell death protein 1 (PD-1) is a cell surface receptor and a vital inhibitor of the immune response. Programmed death ligand 1 (PD-L1) is a trans-membrane co-...
Jamieson, Amy et al. “Clinical Behavior and Molecular Landscape of Stage I p53-abnormal Low-Grade Endometrioid Endometrial Carcinomas.”Clinical cancer research : an official journal of the American Association for Cancer Research, 10.1158/1078-0432.CCR-23-1397. 29 Sep. 2023,doi:10.1158/1078-043...
张杰-聊城:@廖芝玲_广西肿瘤医院 是的,临床治疗一样,往浆液报更安全!不用纠结。 廖芝玲_广西肿瘤医院:好,我觉得这是集二者于一体的癌 掌心0164@汪俊:@廖芝玲_广西肿瘤医院 看看您这个病例符合不符合p53阳性的子宫内膜样腺癌? 掌心0164@汪俊: D EFI...
This approach has enabled the integration of IHC as a standard diagnostic marker for the “p53 abnormal” molecular subtype in endometrial cancer, which is associated with high-risk disease [5]. However, the clinical significance of immunohistochemical pattern analysis of p53 expression in BC remains...
目的:本研究对汕头大学附属粤北人民医院经过病理学检查确诊为子宫内膜癌(Endometrial Cancer,EC)的临床资料进行回顾性分析,通过免疫组化(Immunohistochemistry IHC)检测错配修复(Mismatch Repair,MMR)蛋白和p53蛋白,旨在探索简化后的ProMisE分子分型的临床实践可行性和对生存预后的判断价值.方法:收集2018年1月-2020年12月粤...
--p53异常过表达(p53 abnormal overexpression, OE):通常是TP53的错义突变,突变位点通常在DBD的中心位置 --p53异常完全缺失(p53 abnormal complete absence, CA):通常是TP53发生无义、移码、剪接或缺失突变,导致p53免疫组化所用抗体无法识别的突变p53的抗原表位,表现为IHC阴性 ...