P ATHOLOGY H ISTOLOGY • Diagnostically ambiguous, p53-positive tumors fall into three general categories: 1. Tumors with variable histology, part of which is clas-sically serous carcinoma. The latter exhibits the typical papillary, microp...
Copy number high endometrial carcinomap53 abnormal endometrial carcinomaEndometrial carcinoma with 53 mutationAmong the 4 molecular subgroups of endometrial carcinoma, the p53 abnormal (copy number high) subgroup has the worst prognosis; however, the histologic characteristics of this subgroup are not well...
The presence of an endometrioid component in such tumors seems to have no impact on the survival.4 Endometrial serous carcinomas are usually described as tumors with a prominent papillary architecture, markedly atypical nuclei, and frequent association with psammoma bodies.6 Although many uterine ...
tumors carrying mutp53 exhibit more aggressive and metastatic properties [9,10,11]. GermlineTP53mutations are the cause of Li-Fraumeni syndrome, which predisposes to a variety of early-onset cancers including breast carcinomas, sarcomas, brain...
To eliminate germline CNVs, the authors of the study measured the periodicity of SCNVs (Somatic copy number variations) in hepatocellular carcinoma by subtracting SCNVs from paired non-tumor liver tissues. In this study, lncRNA-PRAL was transcribed with a poly A+ tail and localized to the ...
serousendometrialintraepithelialcarcinoma(EIC)uterinecancerA 69-year-old postmenopausal woman was referred because she had been taking tamoxifen for four years. Tissues obtained by endometrial curettage were immunopositive for p53, but there was no definite malignancy. At age 73, cytology again showed ...
Evidence for a latent precur- sor( p53 signature) that may precede serous endometrial intraepi- thelial carcinoma[J]. Mod Pathol,2009,22( 3) : 345 - 350.Jarboe EA, Pizer ES, Miron A, Monte N, Mutter GL, Crum CP: Evidence for a latent precursor (p53 signature) that may precede ...
Macwhinnie N,Monaghan H.The use of P53, PTEN, and C-erbB-2 to differentiate uterine serous papillary carcinoma from endometrioid endometrial carcinomaint. J Gynecol Cancer . 2004Macwhinnie N, Monaghan H. The use of P53, PTEN and C-erb-2 to differentiate uterine serous papil- lary carcinoma...
1a). For statistical comparisons, cases with p53-stained nuclei of total tumour cells exceeding 20% or completely absent in tumour cells were defined as “p53-positive”. There was no uniform opinion about how to evaluate PD-L1 expression in IHC.6 According to previous reports, the threshold ...
Prognostic Importance of PTEN, p53, and MDM2 Expressions in Endometrioid and Serous-Type Endometrial Carcinomasdoi:10.37990/medr.1486449Acat, SibelCelik, Zeliha EsinGuler, Abdul HamidCelik, CetinMedical Records