The ensuing oxidative stress and the inability of the body to adequately overcome it are, to a large extent, responsible for the pathophysiology of these diseases. This article provides an overview of the main players and control mechanisms involved in the establishment of oxidative stress in these...
Oxidative stress is a component of many diseases, including atherosclerosis, chronic obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small molecules evaluated as antioxidants have exhibited therapeutic potential in preclini
Major diseases, now even diabetes Type 2, are being considered as ‘redox disease’ [33]. Molecular insight will enhance the thrust of the concept of oxidative stress, which is intimately linked to cellular energy balance. Thus, the subcellular compartmentation of redox processes and redox ...
3.1. Neurodegenerative Diseases Oxidative stress and oxidative protein damage can accelerate the formation of toxic protein oligomers and aggregates in the nucleus and cytoplasm of nerve cells, which contributes to the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson...
RPE cells can be disrupted under oxidative stress conditions, but how this influences macular degeneration is unclear. Jeong-Ki Min and Sang-Hyun Lee at the Korea Research Institute of Bioscience and Biotechnology in Daejeon, South Korea, and co-workers found that oxidative stress reduces levels ...
Oxidative stress and cardiomyocyte apoptosis play critical roles in doxorubicin (DOX)-induced cardiotoxicity. Previous studies indicated that fibronectin type III domain-containing 5 (FNDC5) and its cleaved form, irisin, could preserve mitochondrial func
there are several hypotheses concerning the mechanisms that lead to the damage and death of brain cells in neurodegenerative diseases, such as excitotoxic effects by excitatory amino acids, disturbed cellular energy metabolism, and oxidative stress (OS), which is caused by free radicals or other rea...
Furthermore, we assessed the same markers in patients exposed or nonexposed to immunosuppressive treatment. Consistent with a previous study of oxidative stress molecules in other neurodegenerative diseases [29], we chose a panel composed of the following markers: Coenzyme-Q10 (CoQ10); total (GSTot...
Oxidative stress and digestive diseasesEdited by Toshikazu Yoshikawa. 182 pp. $128.75. S. Karger Publishers, Inc., Basel, UK, 2001. ISBN 3-8055-7230-1. Web address for ordering: www.karger.comdoi:10.1016/j.gastro.2003.04.001GavinE
Oxidative Stress and Chronic Degenerative diseases-a Role for Antioxidants (2013), p. 209 Google Scholar [55] S.K. Srivastava, K.V. Ramana, A. Bhatnagar Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options Endocr. Rev., 26 (May (3)...