The review summarizes the impact of oxidative stress on the onset of movement disorders at the molecular level. Oxidative stress is inescapable component of mitochondrial respiration, since the latter represents
Oxidative insults, whether over-excitation, excessive release of glutamate or ATP caused by stroke, ischemia or inflammation, exposure to ionizing radiation, heavy-metal ions or oxidized lipoproteins may initiate various signaling cascades leading to apoptotic cell death and neurodegenerative disorders. Amon...
Oxidative stressrefers to a pathologic state raised from the imbalance betweenROSand capacity of the cell to detoxify it, an obstruction in the process leads to severe harm to allmacromolecules(protein,lipid, and DNA) and interfere with many communication pathways.58The brain has a relatively large...
Various environmental factors such as smoking and dietary habits are known to increase the risk for many diseases associated with aging. These factors link oxidative stress, cellular senescence, and microbial assault to the host. Oxidative stress has been associated with many aging disorders including ...
Oxidative stress has been implicated in the progression of Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Oxygen is vital for life but is also potentially dangerous, and a complex system of checks and balances exists for util
High levels of seminal oxidative stress lead to sperm DNA damage and male factor infertility. In this review, the authors describe the mechanisms of oxidative-stress-induced male factor infertility, and how lifestyle-related interventions might reduce le
there are several hypotheses concerning the mechanisms that lead to the damage and death of brain cells in neurodegenerative diseases, such as excitotoxic effects by excitatory amino acids, disturbed cellular energy metabolism, and oxidative stress (OS), which is caused by free radicals or other rea...
Thorough presentation of these disorders with an emphasis on neurogenerative conditions but includes many others and is not limited to any one organ Part of the book series:Oxidative Stress in Applied Basic Research and Clinical Practice(OXISTRESS) ...
Oxidative Stress, Sex, and Hypertension Oxidative Stress: A Unifying Mechanism in the Hypertension Mosaic Vasoactive Factors, Oxidative Stress, and the Vasculature Aldosterone, Oxidative Stress, and Hypertension Oxidative Stress and Inflammation in Hypertension Immunoinflammation, Oxidative Stress, and Hypertens...
Besides the genetic, biochemical and neuropathological analogies between Down's syndrome (DS) and Alzheimer's disease (AD), there is ample evidence of the involvement of oxidative stress (OS) in the pathogenesis of both disorders. The present paper reviews the publications on DS and AD in the...