Oxidative stress is a component of many diseases, including atherosclerosis, chronic obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small molecules evaluated as antioxidants have exhibited therapeutic potential in preclini
Oxidative stressis the unifying mechanism for many cardiovascular risk factors, which additionally supports its central role in cardiovascular diseases. Oxidative biomarkers such as oxidized LDL-C (derived from the biochemical modification of LDL-C), lectin-like oxidized LDL receptor-1 (mediating the re...
Thus, the dysregulation of Nrf2-regulated genes provides a logical explanation for the connections, both direct and indirect, between observable oxidative stress and perhaps 200 human diseases involving these various physiological processes, each reflecting a network involving many gene products. The ...
EMT-inducing ROS can be endogenously generated from the activation of ROS-producing enzymes, general oxidative stress, or by stromal cells within tumor niche. Indeed, the emerging mechanism paradigm by which ROS induces EMT is not absolute but strongly depends on the cellular context and tissue typ...
This work aims to investigate the role of NOX-mediated oxidative stress as a mechanism for increased BBB permeability in blast-induced traumatic brain injury, immediately following blast and further increase between blast and 4 hours post-blast. Using apocynin, which inhibits the assembly of variou...
Oxidants and Antioxidants in Viral Diseases: Disease Mechanisms and Metabolic Regulation symptoms but also decrease the long-term effects of chronic oxidative stress, which have been linked to the development of cancer in some viral infections... P Ernst - 《Journal of Nutrition》 被引量: 358发表...
The present review we will discuss the dual character of tea polyphenols, both antioxidant and pro-oxidant properties, in some human diseases induced by oxidative stress. 展开 关键词: oxidative stress tea polyphenols antioxidant capacity pro-oxidant capacity ...
Diseases such as hypertension, atherosclerosis, hyperlipidemia, and diabetes are associated with vascular functional and structural changes including endot... RM Touyz - 《Brazilian Journal of Medical & Biological Research》 被引量: 623发表: 2004年 Oxidative stress and endothelial dysfunction in hypertens...
Oxidative stress, mitochondrial dysfunction and neurode- generative diseases; a mechanistic insight. Biomed Pharmacother 2015; 31(74): 101-110.A. H. Bhat, K. B. Dar, S. Anees et al., "Oxidative stress, mito- chondrial dysfunction and neurodegenerative diseases; a mech- anistic insight," ...
The chronic oxidative stress in SCD and β-thalassaemia PMNs results in a reduced respiratory burst response, which is a mechanism of destroying engulfed bacteria, and thus leads to recurrent infections [9]. NADPH oxidase is not only responsible for ROS production in leucocytes but also in RBCs....