The research on the genetics of inherited forms notably ALS, AD, PD, has improved our understanding of the pathobiology of the sporadic forms of neurodegenerative diseases or of aging of the brain. ROS and RNS, i.e. oxidative stress, are not the origin of neuronal death. The cascade of ...
Oxidative stressis the unifying mechanism for many cardiovascular risk factors, which additionally supports its central role in cardiovascular diseases. Oxidative biomarkers such as oxidized LDL-C (derived from the biochemical modification of LDL-C), lectin-like oxidized LDL receptor-1 (mediating the re...
Oxidative stress has been implicated in the progression of a number of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis(ALS). These diseases are characterized by extensive oxidative damage to lipids, proteins and DNA. This dama...
Oxidative stressBiomarkersChronic kidney diseaseExaggerated oxidative stress (OS) is usually considered as a disturbance in regular function of an organism. The excessive levels of OS mediators may lead to major damage within the organism's cells and tissues. Therefore, the OS-associated biomarkers ...
Oxidative stress also seems to have a role in the ageing of the endocrine system and in the pathogenesis of several endocrine diseases How oxidative stress causes ageing in endocrine tissues is unclear; in some tissues, inflammation is probably the link between the two processes ...
leading to the production of superoxides and subsequent mitochondrial and cytosolic oxidative stress. Defects in metabolic and vascular pathways intersect with oxidative stress to produce the onset and progression of nerve injury present in diabetic neuropathy. These pathways include the production of advan...
However, the mechanism and pathways through which oxidative stress affects these diseases are not yet clear. For example, under systemic exposure to oxidative stress, the phospholipids containing polyunsaturated fatty acids (PUFAs) are highly prone to oxidation which induces chemical modifications and ...
Oxidative Stress and Inflammation Products Chronic inflammation and oxidative stress are major causes of cancer and age-related diseases. Boster is proud to offer ELISA kits for oxidative stress, inflammation, stress hormones, small molecules, and mo...
This traditional definition of oxidant stress has been modified, because it is now clear that such an imbalance might be localized to subcellular compartments, such the mitochondria, the nucleus, or localized at the cellular Superoxide Radical Superoxide, produced by 1-electron reduction of molecular ...
This review includes source of free radical generation, chemistry and biochemistry of ROS/RNS and mitochondrial dysfunction and the mechanism involved in neurodegenerative diseases. Introduction Potential biological damage are caused due to harmful effects of free radicals called as oxidative stress and ...