Oxidative stressReactive oxygen speciesAntioxidantDiseaseThe evolution of aerobic metabolic processes such as respiration unavoidably led to the production of reactive oxygen and nitrogen species (ROS and RNI) in mitochondria and peroxisomes of human. A common feature among the different ROS types is ...
It is well known that oxidative stress of reactive oxygen species (ROS) may be a causative factor in the pathenogenesis of bone disorder on osteoblast or osteoclast. The purpose of this study was to evaluate the cytotoxicity of oxidative stress, protective effect of glutamate receptor antagoinst...
Statins, inhibitors of hydroxy methyl glutaryl coenzyme-A (HMG-CoA) reductase, are the most widely used drugs for treating hypercholesterolemia. However, statins can cause disabling myopathy as their main adverse effect. Several molecular mechanisms underlie the statin-induced myopathy including the decre...
Oxidative stress plays a critical role in AD and can even be considered a crucial central factor in the pathogenesis of AD. Previous reviews have also summarized the role of oxidative stress in AD, but these mainly review a specific signaling pathway. Taking oxidative stress as the central ...
Therefore, it might be concluded that lead could promote HMCs' oxidative stress and apoptosis, which may be the chief mechanisms of lead-induced nephrotoxicity. 展开 关键词: Apoptosis human mesangial cells lead acetate nephrotoxicity oxidative stress ...
a他们当中或多或少有人逃过课 In the middle of them the more or less some people have run away the class[translate] aOxidative stress and antioxidant defense system 氧化重音和抗氧化防御系统[translate] a她的成功不仅归功于武 Not only her success gives credit to military[translate] ...
Susceptibility of the parasite to ROS in vitro; 2. macrophage-based defense mechanisms against the parasite in vivo; 3. successful therapy using agents which lead to oxidative stress; 4. selection advantage (with respect to parasite infections) of human populations whose antioxidant capacity is ...
This review examines the hypothesis that oxidative stress is an initiating factor for the development of maturity onset cataract and describes the events leading to lens opacification. Data are reviewed that indicate that extensive oxidation of lens protein and lipid is associated with human cataract fo...
The role of oxidative stress in chronic cadmium (Cd) toxicity and its prevention by cotreatment with antioxidants was investigated. Adult female Sprague-Dawley rats were injected sc with 5 micromol CdCl2/kg/day, 5 times a week, for up to 22 weeks. Serum alanine amino transferase and lactate...
These include: oxidative stress; excitotoxicity caused by aberrant glutamate signalling; mitochondrial dysfunction; disruption of the neurofilament network and intracellular trafficking along neurofilaments; aggregation of proteins; and involvement of non-neuronal cells in the vicinity of motor neurons. One ...