The research on the genetics of inherited forms notably ALS, AD, PD, has improved our understanding of the pathobiology of the sporadic forms of neurodegenerative diseases or of aging of the brain. ROS and RNS, i.e. oxidative stress, are not the origin of neuronal death. The cascade of ...
and how the different roles of oxidative stress can be studied using biomarkers. We will first summarize some basic concepts of causation. Then we will provide some examples of the causal role of oxidative stress in toxicology and in the aetiology of...
Therefore, the OS-associated biomarkers may be considered as new diagnostic tools of various diseases. In nephrology, researchers are looking for alternative methods replacing the renal biopsy in patients with suspicion of chronic kidney disease (CKD). Currently, CKD is a frequent health problem in ...
Oxidative Stress and Inflammation Products Chronic inflammation and oxidative stress are major causes of cancer and age-related diseases. Boster is proud to offer ELISA kits for oxidative stress, inflammation, stress hormones, small molecules, and mo...
The “big three” infectious diseases HIV/AIDS, tuberculosis, and malaria were collectively responsible for nearly 260 million infected people in 2010. HIV, Mycobacterium tuberculosis, and Plasmodium falciparum, the causative agents of AIDS, tuberculosis
pathogenesis, the development of compounds with improved mitochondrial targeting and enhanced antioxidant activity will be key to oxidative stress-based approaches to treating human cardiovascular diseases. In addition to new and more efficacious mitochondrial ROS scavenging compounds, given that ROS can ...
Cardiovascular diseases (CVDs) are the leading cause of death worldwide and rising health care costs [1]. Irreversible heart injury is the main culprit for the poor prognosis of CVDs. Therefore, understanding how cardiac tissue is impaired is critical to global health. Oxidative stress plays an ...
respectively [10,16]. In fact, oxidative stress has been suggested to play a primary or secondary role in the development of multiple (> 100) acute and chronic human diseases [17]. To summarize, RONS are not inherently harmful; however, in response to chronic exposure to excessive and/or ...
Oxidative stress has been proposed as a potential factor involved in the pathophysiology of the disease. Reactive oxygen species have been implicated in the pathogenesis of many human diseases and aging 16, 17. We provide an overview of studies associating oxidative stress with peritoneal endometriosis...
A recurrent theme seen among stressors common to multiple liver diseases is the induction of mitochondrial dysfunction, increased reactive oxygen species expression, and depletion of ATP. Inflammatory signaling additionally exacerbates the condition, generating a proinflammatory, immunosuppressive microenvironment...