Oxidative stress (OS) is associated with a long list of diseases including cancers. It is well established that OS is implicated in different stages of carcinogenesis such as initiation, promotion, progression, and metastasis. Conversely, accumulation of lethal concentrations of reactive oxygen species...
The pathophysiologies of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and Alzheimer’s disease (AD), are far from being fully explained. Oxidative stress (OS) has been proposed as one factor that plays a potential role in the pathogenesis o...
and cognitive abnormalities associated with a significant impediment tosocial life. Each of the diseases in question:Alzheimer's disease,schizophrenia, depression, andbipolar disorder, is characterized by excessiveoxidative stress. Considerable damages to DNA,RNA, proteins,lipids, and mitochondrial dysfunction...
An imbalance between the production of ROS and/or RNS and the activity of the antioxidant defense systems result in oxidative stress, which contributes to rheumatoid arthritis (RA) pathology. The functioning of immune cells is influenced by alterations in the intracellular redox balance. Synovial ...
For this reason, oxidative stress has been implicated in a growing list of human diseases such as cancer, atherosclerosis, Parkinson’s disease, heart failure, myocardial infarction, Alzheimer’s disease, fragile X syndrome, etc., as well as in the aging process. Chronic heart disease is the ...
Various environmental factors such as smoking and dietary habits are known to increase the risk for many diseases associated with aging. These factors link oxidative stress, cellular senescence, and microbial assault to the host. Oxidative stress has been associated with many aging disorders including ...
Alzheimer’s disease (AD) is the most prevalent dementia disorder globally, and there are still no effective interventions for slowing or stopping the underlying pathogenic mechanisms. There is strong evidence implicating neural oxidative stress (OS) and
3.1. Neurodegenerative Diseases Oxidative stress and oxidative protein damage can accelerate the formation of toxic protein oligomers and aggregates in the nucleus and cytoplasm of nerve cells, which contributes to the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson...
The “big three” infectious diseases HIV/AIDS, tuberculosis, and malaria were collectively responsible for nearly 260 million infected people in 2010. HIV, Mycobacterium tuberculosis, and Plasmodium falciparum, the causative agents of AIDS, tuberculosis
Genetic deletion of Atg genes revealed the critical roles of autophagy in physiological adaptation to stress and also a connection between defective autophagy and various diseases. Atg proteins are comprised of four major functional groups: (1) the Atg1/unc-51-like kinase (ULK) complex (Atg1/...