These mice containtransgenicinserts for mouse Tcra-V2 and Tcrb-V5 genes. The transgenic T cell receptor was designed to recognize ovalbumin residues 257-264 in the context ofH2Kband used to study the role ofpeptidesin positive selection and the response of CD8+ T cells to antigen. Like mos...
品系名称:OT-1 Mice品系背景:C57BL/6J毛色:黑色相关基因型:a/a 品系描述 OT1/OT2小鼠T细胞受体(TCR)转基因鼠,都是B6背景。 OT-1小鼠有Tcra-V2与Tcrb-V5基因的插入突变,CD8+ T细胞受体特异性识别OVA 257-264肽段,可用于研究多肽在CD8+T细胞对抗原的阳性选择和应答中的作用。和大多数转基因TCR一样,这些...
Elimination and re-induction of OVA expressing hepatocytes in OVA_X_OT-1 mice.Marcin CebulaAaron OchelUpneet HillebrandMarina C. PilsReinhold SchirmbeckHansjörg HauserDagmar Wirth
with cells transgenic for ovalbumin or by direct administration of ovalbumin. These mice are often used to study CD8+ T cell response to antigen, positive selection, and in any research requiring CD8+ T cells of defined specificity. Like most TCR transgenics, these mice are somewhat immuno...
Interestingly, loss of imprinting of Cdkn1c occurs in ΔKcnq1ot1 mice (Mancini-Dinardo et al., 2006). However, the significance of H3K27me3 enrichment both at 5′ and 3′ ends of the Cdkn1c gene in ΔKcnq1ot1 mice remains to be investigated. The Kcnq1ot1 promoter, which is ...
4,5 Furthermore, elevation of neutrophil recruit-ment, myeloperoxidase (MPO) activity, and reactive oxygen species(ROS) found in lungs from ARDS mice favors the formation ofneutrophil extracellular traps (NETs). 6 NETs, representing adanger-associated molecular pattern, associate with inf l amma...
Transgenic TCR mice are often used experimentally as a source of T cells of a defined specificity. One of the most widely used transgenic TCR models is the OT-1 transgenic mouse in which the CD8+ T cells express a TCR specific for the SIINFEKL peptide of
16 Acampora D, Mazan S, Avantaggiato V et al: Epilepsy and brain abnormalities in mice lacking the Otx1 gene. Nat Genet 1996; 14: 218–222. 17 Robinson PD, Schutz CK, Macciardi F, White BN, Holden JJ: Genetically determined low maternal serum dopamine beta-hydroxylase levels and the ...
The study aimed to investigate the mechanism and biological roles of long noncoding RNAKCNQ1OT1 in adipogenic and osteogenic differentiation of tendon stem cell. In this study, tendon injury mice model was established to detect the expression of lncRNA KCNQ1OT1, miR-138, peroxisome proliferator-...
The resulting phenotypes in mouse models are remarkably different: Kmt2c depleted mice die after birth without morphological alterations, whereas Kmt2d KO mice die during embryonic development, at embryonic stage E9.5, due to defects in heart development, adipogenesis, and myogenesis. In addition, ...