品系名称:OT-1 Mice 品系背景:C57BL/6J 毛色:黑色 相关基因型:a/a 品系描述 OT1/OT2小鼠T细胞受体(TCR)转基因鼠,都是B6背景。 OT-1小鼠有Tcra-V2与Tcrb-V5基因的插入突变,CD8+ T细胞受体特异性识别OVA 257-264肽段,可用于研究多肽在CD8+T细胞对抗原的阳性选择和应答中的作用。和大多数转基因TCR一样,...
We used mice with genetic modifications in three major pathways used by CTL, perforin, Fas and pro-inflammatory cytokines to assess the relative contribution of these mechanisms to beta cell death. In vitro-activated ovalbumin (OVA)-specific CTL, from OT-I TCR-transgenic mice, specifically killed...
We used mice with genetic modifications in three major pathways used by CTL, perforin, Fas and pro-inflammatory cytokines to assess the relative contribution of these mechanisms to beta cell death. In vitro-activated ovalbumin (OVA)-specific CTL, from OT-I TCR-transgenic mice, specifically killed...
with cells transgenic for ovalbumin or by direct administration of ovalbumin. These mice are often used to study CD8+ T cell response to antigen, positive selection, and in any research requiring CD8+ T cells of defined specificity. Like most TCR transgenics, these mice are somewhat immuno...
OT-I: (CD8+---ovalbumin 257-264 )These mice contain transgenic inserts for mouse Tcra-V2 and...
miR-155 Overexpression Is Associated with Enhanced Metabolic Activity of OT-1 Cells miR-155 is important in controlling the signaling pathways downstream of T cell receptor (TCR) activation. Indeed, miR-155 overexpression decreases the intracellular amount of its target INPP5D and thus, augments the...
OT-I:(CD8+---ovalbumin 257-264 )These mice contain transgenic inserts for mouse Tcra-V2 and ...
OT-I: (CD8+---ovalbumin 257-264 )These mice contain transgenic inserts for mouse Tcra-V2 and...
mice are also called BXSB.Yaa Tg(TcraTcrb)1100 mice or BXSB.Yaa OT-1 TCR transgenic mice....
网友 1 最佳答案 回答者:网友 OT-II: (CD4+---ovalbumin 323-339 )These transgenic mice express the mouse alpha-chain and beta-chain T cell receptor that pairs with the CD4 coreceptor and is specific for chicken ovalbumin 323-339 in the context of I-A b. Homozygous mice are viable and...