Finally, we define implementation limitations and requirements for translation of the integrated devices, including determining the differentiation stage at which an organoid should be placed into an organ-on-a-chip device, providing perfusable vasculature within the organoid and overcoming limitations of ...
Organ-on-a-chip has emerged as a new technique for constructing normal or diseased models in vitro, attracting rapidly increasing attention from researchers and clinics. Similar to other traditional methods, the main advantages of organ-on-a-chip are its high portability, high throughput and abilit...
Reconstituting organ-level lung functions on a chip. Science 328, 1662–1668 (2010). This paper is one of the pioneering works on lung OoC, which demonstrates a functional alveolar–capillary interface that is responsive to pathogen infection. ADS Google Scholar Ronaldson-Bouchard, K. & Vunjak...
Finally, we define implementation limitations and requirements for translation of the integrated devices, including determining the differentiation stage at which an organoid should be placed into an organ-on-a-chip device, providing perfusable vasculature within the organoid and overcoming limitations of ...
The feasible application ofmicrofluidic tissue/organ-on-a-chip as an impersonator of oral tissues and organs:a direction for future research Currently,cell culture models play a key role in determining cell behavior under various conditions.However,the accurate simulation of cellular behavior th... ...
Organs-on-a-chip: a new paradigm for toxicological assess- ment and preclinical drug development. Toxicol Res Appl. 2017;1:1-16... D Bovard,A Iskandar,K Luettich,... - 《Toxicology Research & Application》 被引量: 4发表: 2017年 Controlling Differentiation of Stem Cells for Developing Pers...
Organ-on-a-chip systems have been increasingly recognized as attractive platforms to assess toxicity and to develop new therapeutic agents. However, current organ-on-a-chip platforms are limited by a “single pot” design, which inevitably requires holistic analysis and limits parallel processing. He...
Find out more about the organ-on-a-chip models, their advantages and future developments in our Topic of the Month.
A multiorgan-on-a-chip (MOC) device consisting of breast and liver compartments was designed with AutoCAD software. The MOC molds were printed by a Formlabs Form 2 3D printer. MDA-MB-231, HepG2, and MCF-10 A cells were used for the MOC experiments. The cell lines were cultured at ...
Research in this direction that employs organ-on-chip-related approaches for cell migration analysis has been increasingly reported in recent years. In this paper, we briefly introduce the general background of cell migration and organ-on-chip research, followed by a detailed review of specific ...