In this review, we discuss how the Organ-on-a-Chip technology can have critical roles in different preclinical stages of drug development and highlight the current challenges in translation and commercialization of this technology for the pharmacological and medical end-users. Moreover, this review ...
In this Review, we discuss how organ-on-a-chip technologies can recreate functions of organs, focusing on tissue barrier properties, parenchymal tissue function and multi-organ interactions, which are three key aspects of human physiology. Specific organ-on-a-chip systems are examined in terms of...
Review ReportsVersions Notes Abstract Organ-on-a-chip (OOC) provides microphysiological conditions on a microfluidic chip, which makes up for the shortcomings of traditional in vitro cellular culture models and animal models. It has broad application prospects in drug development and screening, toxicolog...
Organ-on-a-chip devices advance to market. Lab Chip 17, 2395–2420 (2017). This review discusses the commercialization trajectory of OoC technologies into the drug discovery market. Google Scholar Verpoorte, E. et al. in 2015 Transducers — 2015 18th International Conference on Solid-State ...
Finally, we define implementation limitations and requirements for translation of the integrated devices, including determining the differentiation stage at which an organoid should be placed into an organ-on-a-chip device, providing perfusable vasculature within the organoid and overcoming limitations of ...
It is commonly used to precisely control microfluidic (10−9 to 10−18 L) fluids using channels that range in size from tens to hundreds of microns and is known as a “lab-on-a-chip” [1,2,3,4]. The microchannel is small, but has a large surface area and high mass transfer,...
Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University have shown that their “lung-on-a-chip” technology can mimic a life-threatening lung condition. They also report that scientists can uncover new aspects of the disease using the lung chip that would not ...
This review introduces recent advances from OOAC technology and discusses its future perspectives for cell biological assessments. Organs-on-a-chip design concept and key components Design concept Culture systems require the control of external and internal cell environments [28]. OOAC combined with mi...
Organ-on-a-Chip: New Platform for Biological Analysis Direct detection and analysis of biomolecules and cells in physiological microenvironment is urgently needed for fast evaluation of biology and pharmacy. T... Y Luo,A Fan,Y Qu,... - 《Anal Chem Insights》 被引量: 5发表: 2015年 Encapsula...
Organ-on-a-chip devices can replicate key aspects of human physiology crucial for the understanding of drug effects, improving preclinical safety and efficacy testing. In this Review, we discuss how organ-on-a-chip technologies can recreate functions of organs, focusing on tissue barrier properties...