However, there are challenges to demonstrate the 'gain of confidence' of this technology for patient benefit. Translational challenges, the opportunities and deficiencies of the organ models, their intercommunication and the platform technology are all issues to be resolved. Sensitive, real-time ...
Current in vitro and in vivo preclinical models often have limited predictive value for translation to the clinical setting. The emerging ‘Organ-on-a-Chip’ (OOC) technology provides a better resemblance to the human physiology through combining 3D configuration of human-derived cells with microfluid...
For more than a century, DILI has exacted a significant toll on unsuspecting patients. However, the advent of organ-on-a-chip technology—specifically the Liver-Chip—has inspired a growing hope that DILI will no longer be a threat that looms over drug development projects. With the ability ...
New Technology to Minimize Animal Model UseOne further benefit to the continued development of this technology is the minimization of the use of animals in medical research. While I believe that “you need a liver and circulatory system to do drug discovery” that doesn’t necessarily mean the ...
Organ-on-a-chip technology, based on microfluidics, can better simulate the cellular microenvironment in vivo, opening a new field for the basic and clinical research of female reproductive system diseases. This technology can not only reconstruct the organ structure but also emulate the organ ...
Organ-on-a-chip technology is purported to be game changing, serving as a testing alternative that is replacing the use of animals in life science across life science research, toxicology testing and drug development studies across the globe. Historically, it has been observed that pharmaceutical ...
and B.Z. are inventors on an issued US patent for Biowire technology that is licensed to Valo Health; they receive royalties for this invention. B.Z. and S.R. are co-founders and hold equity in OrganoBiotech. The remaining authors declare no competing interests. Peer review Peer review ...
Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University have shown that their “lung-on-a-chip” technology can mimic a life-threatening lung condition. They also report that scientists can uncover new aspects of the
Explore the varying application areas that PhysioMimix OOC helps support PhysioMimix application areas Services Access the power of PhysioMimix through our contract research service Our OOC services Resources Dive deeper into our technology through app notes, scientific publications and much more Browse ou...
Finally, the MOC section shows how the organ on a chip technology can be adapted to improve the physiology of in-vitro models. Key Features Includes case studies of other organs on a chip that have been developed and successfully used Provides insights into functional microphysiological organ on ...