One important step for organ-on-a-chip is to capture cells, thus some microstructures are usually integrated in the chip to trap cells when the suspension is ejected into chip. To predict and evaluate the cell capture efficiency, we developed an Euler-Lagrange numerical model to simulate the ...
Curiochips are organ on a chip designed to recapitulate the complexity of tissue microenvironments for biomedical research.
Find out more about the organ-on-a-chip models, their advantages and future developments in our Topic of the Month.
Organ-on-a-chip platforms have been the first step forward, leading to the combination and integration of multiple organ models in the same platform with human-on-a-chip being the ultimate goal. Despite the current progress and technological developments, there are still several unmet engineering ...
Organs-on-a-chip design concept and key components Design concept Culture systems require the control of external and internal cell environments [28]. OOAC combined with micromachining and cell biology can control external parameters and accurately simulate physiological environments [16]. Dynamic mechani...
Organ-on-a-chip has emerged as a new technique for constructing normal or diseased models in vitro, attracting rapidly increasing attention from researchers and clinics. Similar to other traditional methods, the main advantages of organ-on-a-chip are its high portability, high throughput and abilit...
OOAC was proposed as a future replacement technology for experimental animal models [27]. This review introduces recent advances from OOAC technology and discusses its future perspectives for cell biological assessments. Organs-on-a-chip design concept and key components...
Design and fabrication of a liver-on-a-chip platform for convenient, highly efficient, and safe in situ perfusion culture of 3D hepatic spheroids. Lab Chip 18, 2547–2562 (2018). Google Scholar Zhao, Y. et al. A platform for generation of chamber-specific cardiac tissues and disease ...
Design and fabrication of a liver-on-a-chip platform for convenient, highly efficient, and safe in situ perfusion culture of 3D hepatic spheroids. Lab Chip 18, 2547–2562 (2018). Google Scholar Zhao, Y. et al. A platform for generation of chamber-specific cardiac tissues and disease ...
Organ-on-a-chip devices have enabled major breakthroughs in biomedical research, but they have yet to be successfully translated to the pharmaceutical industry. Traditional microfluidic devices rely on irreversible bonding techniques to seal fluidic channels, which limit their accessibility and automation ...