Organ-on-a-chip has emerged as a new technique for constructing normal or diseased models in vitro, attracting rapidly increasing attention from researchers and clinics. Similar to other traditional methods, the main advantages of organ-on-a-chip are its high portability, high throughput and abilit...
A guide to the organ-on-a-chipThis PrimeView highlights the design and fabrication of organ-on-a-chip devices, from material selection to culture medium, pumps and cell or tissue seeding.doi:10.1038/s43586-022-00127-5Nature Publishing Group UKNature Reviews Methods Primers...
MIVO® Platforms ORGAN-ON-CHIP is a new tool to help researchers in studying the complexity of human biology.
Organ-on-a-chip platforms have been the first step forward, leading to the combination and integration of multiple organ models in the same platform with human-on-a-chip being the ultimate goal. Despite the current progress and technological developments, there are still several unmet engineering ...
Organs-on-chips (OoCs) are systems containing engineered or natural miniature tissues grown inside microfluidic chips. To better mimic human physiology, the chips are designed to control cell microenvironments and maintain tissue-specific functions. Comb
1. A self-contained organ-on-a-chip device comprising: at least one organ growth section comprising at least two organ cavities; and a degradable matrix or a micro-channel arranged between the at least two organ cavities, the degradable matrix or the micro-channel being configured to allow fo...
It is commonly used to precisely control microfluidic (10−9 to 10−18 L) fluids using channels that range in size from tens to hundreds of microns and is known as a “lab-on-a-chip” [1,2,3,4]. The microchannel is small, but has a large surface area and high mass transfer,...
Organ-on-a-chip devices have enabled major breakthroughs in biomedical research, but they have yet to be successfully translated to the pharmaceutical industry. Traditional microfluidic devices rely on irreversible bonding techniques to seal fluidic channels, which limit their accessibility and automation ...
the incorporation of fluid into the OOAC device permits biological assessments at the single organ level [31]. The OOAC system summarizes flow through a simple “rocker” on a chip fluid motion, or through a more complex programmable “pulsatile” format, arranged in a single loop for organiz...
LUNG-ON-A-CHIP: THE MICROFLUIDIC “CHIP” SYSTEM As exemplified by Huhet al, microfluidic “chip” solutions require cell seeding into a pair of microfluidic channels separated by a porous membrane.2The porous membrane is formed from an elastomeric material which, when stretched, provides...