This chapter will learn the definition of OOC, fabrication methods (same as those of lab-on-a-chip or LOC), various examples (kidney, liver, lung, angiogenesis, and blood-brain barrier), multiple-organs-on-a-chip, and applications (drug testing and disease model), and addition of ...
Combining advances in tissue engineering and microfabrication, OoCs have gained interest as a next-generation experimental platform to investigate human pathophysiology and the effect of therapeutics in the body. There are as many examples of OoCs as there are applications, making it difficult for ...
Subsequently, we will discuss recent examples of microfluidic models applied to investigate mechanisms of immune-cancer interactions and for developing and screening cancer immunotherapies in vitro. First steps toward their validation for predicting human in vivo outcomes are discussed. Finally, promising ...
Finally, we define implementation limitations and requirements for translation of the integrated devices, including determining the differentiation stage at which an organoid should be placed into an organ-on-a-chip device, providing perfusable vasculature within the organoid and overcoming limitations of ...
Finally, we define implementation limitations and requirements for translation of the integrated devices, including determining the differentiation stage at which an organoid should be placed into an organ-on-a-chip device, providing perfusable vasculature within the organoid and overcoming limitations of ...
Find out more about the organ-on-a-chip models, their advantages and future developments in our Topic of the Month.
Users will learn about the limitations of 2D in-vitro models and the available 3D in-vitro models (what benefits they offer and some examples). Finally, the MOC section shows how the organ on a chip technology can be adapted to improve the physiology of in-vitro models. ...
MOC Multi-organ chip MODY Maturity Onset Diabetes of the Young MPCC Micropatterned co-culture MPS Microphysiological system MSC Mesenchymal stem cell MYH Myosin heavy chain NOD Non-obese diabetic NPC Non-parenchymal cell NPSC Neural progenitor stem cell OoC Organ-on-a-chip PDMS Polydimethylsiloxane PD...
In the past decade, organoid and organ-on-a-chip cancer models have rapidly gained attention as alternatives to traditional two-dimensional cell cultures and murine models. However, they are still relatively “low throughput”—meaning that, similar to animal models, relatively low numbers of replic...
1. A self-contained organ-on-a-chip device comprising: at least one organ growth section comprising at least two organ cavities; and a degradable matrix or a micro-channel arranged between the at least two organ cavities, the degradable matrix or the micro-channel being configured to allow fo...