1. A self-contained organ-on-a-chip device comprising: at least one organ growth section comprising at least two organ cavities; and a degradable matrix or a micro-channel arranged between the at least two organ cavities, the degradable matrix or the micro-channel being configured to allow fo...
human‐on‐a chipmicrofluidicsorgan‐on‐a‐chipOrgan-on-a-chip" systems integrate microengineering, microfluidic technologies, and biomimetic principles to create key aspects of living organs faithfully, including critical microarchitecture, spatiotemporal cell鈥揷ell interactions, and extracellular ...
ORGAN-ON-A-CHIP-DEVICE 专利名称：ORGAN-ON-A-CHIP-DEVICE 发明人：Uwe Marx 申请号：US12996015 申请日：20090604 公开号：US20110086382A1 公开日：20110414 专利内容由知识产权出版社提供 专利附图：摘要：A self-contained organ-on-a-chip device includes at least one medium feed reservoir and at least ...
One of the many applications of organ-on-a-chip (OOC) technology is the study of biological processes in human induced pluripotent stem cells (iPSCs) during pharmacological drug screening. It is of paramount importance to construct OOCs equipped with highly compact in situ sensors that can accur...
www.nature.com/scientificreports OPEN received: 05 April 2016 accepted: 26 July 2016 Published: 25 August 2016 Development of a Functional Glomerulus at the Organ Level on a Chip to Mimic Hypertensive Nephropathy Mengying Zhou1,*, Xulang Zhang2,*, Xinyu Wen1, Taihua Wu1, Weidong...
Research focused on extending the lifespan of these microfluidic devices has been the main focus of many lab- oratories to validate body-on-a-chip systems as models for repeated dose or chronic exposure of compounds for efficacy, toxicity and pharmacokinetic studies. Currently, the toxicology ...
Chang et al., "Fully automated cellular-resolution vertebrate screening paltform with paralle animal procession". Lab on a Chip, 2012, Vol.12, No.4, pp.665-836. World Precision Instruments, “Microinjection Tool Box”, 2014. Mondal et al., “Simple Microfluidic Devices for in vivo Imaging ...
Thus, increase in H2B monoubiquitylation is expected to elicit a reverse effect on these marks. We used qChIP to analyze, in the otu1-1 and otu1-2 plants, the chromatin of the DA1 and DA2 genes for possible changes in their H3K4me3 and H3Ac contents. The chromatin of the DA1 and ...
Expression intensities are on a log2 scale and are based on transcriptomics data with an ATH1 chip (Affymetrix), three independent biological replicates each. Error bars indicate s.d.; asterisks indicate a significant difference (Po0.05, Student's t-test) from wildtype. (b–d) All seedlings...
Interestingly, these CHIPseq data identified a 600-bp promoter fragment localized 1.5 kb upstream of the coding region in the dilp8 locus. Close examination of this fragment reveals three potential Sd-binding sites (hereafter referred to as Hpo-responsive element (HRE))23, suggesting that dilp8 ...