The on-off phenomenon is an almost invariable consequence of sustained levodopa treatment in patients with Parkinson's disease. Phases of immobility and incapacity associated with depression alternate with jubilant thaws. Both pharmacokinetic and pharmacodynamic factors are involved in its pathogenesis, but...
The On–Off Phenomenon in Parkinson's Disease We studied the response to continuous infusion of levodopa and the effects of meals on the plasma levodopa concentrations and on the clinical response during oral and intravenous administration of the drug. Meals reduced peak plasma ... John G. Nutt...
The “on-off” phenomenon in Parkinson’s disease (PD) refers to a switch between mobility and immobility in levodopa-treated patients, which occurs as an end-of-dose or “wearing off” worsening of motor function or, much less commonly, as sudden and unpredictable motor fluctuations. Motor c...
"On-off" phenomenon with levodopa therapy in Parkinsonism. Clinical and pharmacologic correlations and the effect of intramuscular pyridoxine. We evaluated the current status of 131 patients with idiopathic parkinsonism who were receiving levodopa therapy. The residual parkinsonian symptoms and si... Fahn...
Many patients with idiopathic Parkinson's disease treated with levodopa for more than five years develop fluctuations in their clinical response to this drug. Such fluctuations may be unpredictable, but more commonly occur in a regular pattern related to the size and timing of the levodopa dosage....
That’s exactly how we’re treating Parkinson’s disease patients at the moment. There are six different types of medications that can be used to “boost” the dopamine level in patients with Parkinson’s diseases. But today, we will get into the most commonly used of all, calledlevodopa....
The "on-off"phenomenon in Parkinson's disease. Relation to levodopa absorption and transport. Morphology of on-off direction-selective ganglion cells in the rabbit retina. Blowout bifurcations: the occurrence of riddled basins and on-off intermittency ...
Table 1. Terms used to describe “Off” states in Parkinson's Disease due to levodopa therapy. Motor Fluctuations/“Offs” • Wearing off or end-of-dose deterioration • On-Off phenomenon/Sudden “off”/Random “off” • Yo-yo-ing • Early morning akinesia/bradykinesia • Delayed “...
During long-term treatment with L-dopa in Parkinson's syndrome "on-off" phenomenon develops in many cases, often entailing considerable therapeutic problem... J Balldin,S Edén,AK Granérus,... - 《Journal of Neural Transmission》 被引量: 103发表: 1980年 The role of 3-O-methyldopa in th...
The possible mechanism of the "off-on" phenomenon and some suggestions to influence it, are presented. 展开 关键词: Off-On” effect Parkinson disease Levodopa Decarboxylase inhibitor DOI: 10.1007/BF00312550 被引量: 13 年份: 1977