The on-off phenomenon is an almost invariable consequence of sustained levodopa treatment in patients with Parkinson's disease. Phases of immobility and incapacity associated with depression alternate with jubilant thaws. Both pharmacokinetic and pharmacodynamic factors are involved in its pathogenesis, but...
Early onset of the "on-off" phenomenon in children with symptomatic Parkinsonism. Many patients with idiopathic Parkinson's disease treated with levodopa for more than five years develop fluctuations in their clinical response to this dr... A,E,Lang,... - 《Journal of Neurology Neurosurgery & ...
The on-off phenomenon. 喜欢 0 阅读量: 15 作者: AJ Lees 摘要: The on-off phenomenon is an almost invariable consequence of sustained levodopa treatment in patients with Parkinson's disease. Phases of immobility and incapacity associated with depression alternate with jubilant thaws. Both ...
Table 1. Terms used to describe “Off” states in Parkinson's Disease due to levodopa therapy. Motor Fluctuations/“Offs” • Wearing off or end-of-dose deterioration • On-Off phenomenon/Sudden “off”/Random “off” • Yo-yo-ing • Early morning akinesia/bradykinesia • Delayed “...
For someone who experiences the “on-off” effect for the first time, the switch from “on” to “off” happens gradually. The “off” periods are also more predictable and occur near the end of each levodopa dose. For example, when they first begin treatment, many people are placed on...
treatment for PD involves dopaminergic medications, which alleviate symptoms without impeding disease progression [2]. However, prolonged use of these medications may lead to complications such as levodopa-induced dyskinesia [3]. Surgical interventions, such as deep brain stimulation of the subthalamic ...
On-off" symptoms were found to have developed in 43 of 85 parkinsonian patients who had been treated with L-dopa for five years or more, the risk of such symptoms apparently being greater the younger the patient had been at the début of the disease and at the start of treatment....
The diet restriction was not found to be correlated with age, stage, duration of illness or duration of dopa treatment. The possible mechanism of the "off-on" phenomenon and some suggestions to influence it, are presented. 展开 关键词: Off-On” effect Parkinson disease Levodopa Decarboxylase ...
switching “on,” switching “off”359or the phenomenon of the so called “awakening” (Sacks 1982) after surgery. Still, we are talking about a coherent event affecting cells, brain processes, bodies, biographies, partnerships and family structures. Theoretical con-cepts such as autopoiesis, sel...
of 30 PD patients and gave them single oral doses of levodopa (100 or 200 mg p.o.) alone or combined with a MAO-I or with α-methyldopa, a decarboxylase inhibitor. Methyldopa given alone or in combination with levodopa increased the tremor, whereas levodopa reduced the rigidity to half....